Show simple item record

dc.contributor.authorShao, E.
dc.contributor.authorGreen, Adèle C
dc.contributor.authorMiura, K.
dc.date.accessioned2020-11-16T07:49:16Z
dc.date.available2020-11-16T07:49:16Z
dc.date.issued2020en
dc.identifier.citationShao E, Green AC, Miura K. Inflammatory Dietary Patterns and Risk of Keratinocyte Cancers in Kidney Transplant Recipients: Prospective Cohort Study. Dermatology. 2020:1-6.en
dc.identifier.pmid32966976en
dc.identifier.doi10.1159/000509875en
dc.identifier.urihttp://hdl.handle.net/10541/623432
dc.description.abstractBackground: Kidney transplant recipients (KTRs) are at increased risk of cutaneous squamous (SCC) and basal cell carcinomas (BCC) due to immunosuppression and sun exposure. Skin carcinogenesis involves inflammation, and foods that promote inflammation may promote carcinogenesis. Methods: We prospectively examined the association between pro-inflammatory diets and SCC and BCC incidence in KTRs in Queensland, Australia. We recruited KTRs at high risk of skin cancer (aged ?18 years and previously affected; or aged ?40; or immunosuppressed ?10 years) between 2012 and 2014 and followed up until June 2016. A baseline dietary questionnaire was used to calculate modified-Empirical Dietary Inflammatory Pattern (EDIP) scores to indicate dietary inflammatory capacity; higher scores indicated pro-inflammatory diets. EDIP scores were ranked into 3 groups. Outcomes were histologically confirmed SCC and BCC. Adjusted relative risks (RRadj) and 95% CIs were estimated using negative binomial regression. Results: Among 260 KTRs, 100 (38%) and 93 (36%) developed at least 1 new SCC and BCC, with 426 SCC and 343 BCC diagnosed in the follow-up period. The highest modified-EDIP score group (vs. lowest) were at increased risk of SCC (RRadj 1.79, 95% CI 1.01-3.16) but not BCC. Pro-inflammatory diets may increase SCC but not BCC risk among KTRs. Conclusions: Inflammatory diets may increase the risk of SCC in KTRs.en
dc.titleInflammatory dietary patterns and risk of keratinocyte cancers in kidney transplant recipients: prospective cohort studyen
dc.typeArticleen
dc.contributor.departmentQIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, emilyxshao@gmail.com.en
dc.identifier.journalDermatologyen
dc.description.noteen]


This item appears in the following Collection(s)

Show simple item record