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    Inflammatory dietary patterns and risk of keratinocyte cancers in kidney transplant recipients: prospective cohort study

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    Authors
    Shao, E.
    Green, Adèle C
    Miura, K.
    Affiliation
    QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, emilyxshao@gmail.com.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Background: Kidney transplant recipients (KTRs) are at increased risk of cutaneous squamous (SCC) and basal cell carcinomas (BCC) due to immunosuppression and sun exposure. Skin carcinogenesis involves inflammation, and foods that promote inflammation may promote carcinogenesis. Methods: We prospectively examined the association between pro-inflammatory diets and SCC and BCC incidence in KTRs in Queensland, Australia. We recruited KTRs at high risk of skin cancer (aged ?18 years and previously affected; or aged ?40; or immunosuppressed ?10 years) between 2012 and 2014 and followed up until June 2016. A baseline dietary questionnaire was used to calculate modified-Empirical Dietary Inflammatory Pattern (EDIP) scores to indicate dietary inflammatory capacity; higher scores indicated pro-inflammatory diets. EDIP scores were ranked into 3 groups. Outcomes were histologically confirmed SCC and BCC. Adjusted relative risks (RRadj) and 95% CIs were estimated using negative binomial regression. Results: Among 260 KTRs, 100 (38%) and 93 (36%) developed at least 1 new SCC and BCC, with 426 SCC and 343 BCC diagnosed in the follow-up period. The highest modified-EDIP score group (vs. lowest) were at increased risk of SCC (RRadj 1.79, 95% CI 1.01-3.16) but not BCC. Pro-inflammatory diets may increase SCC but not BCC risk among KTRs. Conclusions: Inflammatory diets may increase the risk of SCC in KTRs.
    Citation
    Shao E, Green AC, Miura K. Inflammatory Dietary Patterns and Risk of Keratinocyte Cancers in Kidney Transplant Recipients: Prospective Cohort Study. Dermatology. 2020:1-6.
    Journal
    Dermatology
    URI
    http://hdl.handle.net/10541/623432
    DOI
    10.1159/000509875
    PubMed ID
    32966976
    Type
    Article
    ae974a485f413a2113503eed53cd6c53
    10.1159/000509875
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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