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dc.contributor.authorPillai, Manon
dc.contributor.authorDavies, Michelle
dc.contributor.authorThistlethwaite, Fiona C
dc.date.accessioned2020-11-16T07:49:15Z
dc.date.available2020-11-16T07:49:15Z
dc.date.issued2020en
dc.identifier.citationPillai M, Davies MM, Thistlethwaite FC. Delivery of adoptive cell therapy in the context of the health-care system in the UK: challenges for clinical sites. Ther Adv Vaccines Immunother. 2020;8:2515135520944355.en
dc.identifier.pmid33015538en
dc.identifier.doi10.1177/2515135520944355en
dc.identifier.urihttp://hdl.handle.net/10541/623425
dc.description.abstractAdvanced Therapy Medicinal Products (ATMPs) comprise novel cell, tissue and gene therapies and offer the potential of durable remissions for diseases where there is a high unmet clinical need. Once considered a niche area of academic research, ATMPs now represent one of the fastest-growing areas of clinical development. The field has seen a rapid expansion of academic and commercial entities successfully translating ATMP research into the clinic. This is reflected in projection that the global gene and cell therapy market will be worth US $11.96 billion by 2025. However, these treatments are complex to deliver and frequently do not fit naturally into established healthcare systems. In the United Kingdom (UK) there has been a long-standing interest in ATMP research and, in order to meet the ambition to act as an international hub of activity for delivery of ATMPs, a collaborative network of Advanced Therapy Treatment Centres (ATTCs) has been established. This review explores the challenges of delivery in the clinical setting, focussing on one form of ATMP, Adoptive Cell Therapy (ACT). We describe the strategy being implemented in the UK to optimise the roll-out of these exciting new therapies.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1177/2515135520944355en
dc.titleDelivery of adoptive cell therapy in the context of the health-care system in the UK: challenges for clinical sitesen
dc.typeArticleen
dc.contributor.departmentThe Christie NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalTherapeutic Advances in Vaccines and Immunotherapyen
dc.description.noteen]
refterms.dateFOA2020-11-16T13:08:00Z


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