AuthorsParker, P. J.
Kelly, Joanna R
Soliman, T. N.
Pardo, A. L.
Marshall, J. J. T.
Redmond, J. M.
AffiliationProtein Phosphorylation Laboratory, Francis Crick Institute, London, NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, Guy's Campus, London, SE1 1UL
MetadataShow full item record
AbstractAssociated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data, but has for the most part not afforded clear mechanistic insights into the control mechanisms at play. Here, we review the roles of PKC? in protecting transformed cells from non-disjunction. In this particular cell cycle context, there is a growing understanding of the pathways involved, affording biomarker and interventional insights and opportunities.
CitationParker PJ, Lockwood N, Davis K, Kelly JR, Soliman TN, Pardo AL, et al. A cancer-associated, genome protective programme engaging PKCepsilon. Adv Biol Regul. 2020;78:100759.
JournalAdvances in Biological Regulation
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