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dc.contributor.authorMevel, Renaud
dc.contributor.authorSteiner, Ivana
dc.contributor.authorMason, S.
dc.contributor.authorGalbraith, L. C.
dc.contributor.authorPatel, Rahima
dc.contributor.authorFadlullah, Muhammad Z H
dc.contributor.authorAhmad, I.
dc.contributor.authorLeung, H. Y.
dc.contributor.authorOliveira, Pedro
dc.contributor.authorBlyth, K.
dc.contributor.authorBaena, Esther
dc.contributor.authorLacaud, Georges
dc.date.accessioned2020-11-16T07:49:13Z
dc.date.available2020-11-16T07:49:13Z
dc.date.issued2020en
dc.identifier.citationMevel R, Steiner I, Mason S, Galbraith LC, Patel R, Fadlullah MZ, et al. RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. Elife. 2020;9.en
dc.identifier.pmid33025905en
dc.identifier.doi10.7554/eLife.60225en
dc.identifier.urihttp://hdl.handle.net/10541/623412
dc.description.abstractThe characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral region of the developing and adult mouse prostate, and distinct from the previously identified NKX3.1+ luminal castration-resistant cells. Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1+ PLCs are unaffected by androgen deprivation, and do not contribute to the regeneration of the distal luminal compartments. Furthermore, we demonstrate that a transcriptionally similar RUNX1+ population emerges at the onset of embryonic prostate specification to populate the proximal region of the ducts. Collectively, our results reveal that RUNX1+ PLCs is an intrinsic castration-resistant and self-sustained lineage that emerges early during prostate development and provide new insights into the lineage relationships of the prostate epithelium.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.7554/eLife.60225en
dc.titleRUNX1 marks a luminal castration resistant lineage established at the onset of prostate developmenten
dc.typeArticleen
dc.contributor.departmentStem Cell Biology, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfielden
dc.identifier.journalElifeen
dc.description.noteen]
refterms.dateFOA2020-11-17T09:46:10Z


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