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dc.contributor.authorCheng, S.
dc.contributor.authorCheadle, E. J.
dc.contributor.authorIllidge, Timothy M
dc.date.accessioned2020-11-16T07:49:05Z
dc.date.available2020-11-16T07:49:05Z
dc.date.issued2020en
dc.identifier.citationCheng S, Cheadle EJ, Illidge TM. Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response. Cancers (Basel). 2020;12(10).en
dc.identifier.pmid33008040en
dc.identifier.doi10.3390/cancers12102835en
dc.identifier.urihttp://hdl.handle.net/10541/623361
dc.description.abstractRadiotherapy (RT) is a highly effective anti-cancer treatment. Immunotherapy using immune checkpoint blockade (ICI) has emerged as a new and robust pillar in cancer therapy; however, the response rate to single agent ICI is low whilst toxicity remains. Radiotherapy has been shown to have local and systemic immunomodulatory effects. Therefore, combining RT and immunotherapy is a rational approach to enhance anti-tumour immune responses. However, the immunomodulatory effects of RT can be both immunostimulatory or immunosuppressive and may be different across different tumour types and patients. Therefore, there is an urgent medical need to establish biomarkers to guide clinical decision making in predicting responses or in patient selection for RT-based combination treatments. In this review, we summarize the immunological effects of RT on the tumour microenvironment and emerging biomarkers to help better understand the implications of these immunological changes, and we provide new insights into the potential for combination therapies with RT and immunotherapy.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3390/cancers12102835en
dc.titleUnderstanding the effects of radiotherapy on the tumour immune microenvironment to identify potential prognostic and predictive biomarkers of radiotherapy responseen
dc.typeArticleen
dc.contributor.departmentManchester Academic Health Science Centre, Manchester NIHR Biomedical Research Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchesteren
dc.identifier.journalCancersen
dc.description.noteen]
refterms.dateFOA2020-11-16T12:55:23Z


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