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dc.contributor.authorMiura, K.
dc.contributor.authorWay, M.
dc.contributor.authorJiyad, Z.
dc.contributor.authorMarquart, L.
dc.contributor.authorPlasmeijer, E. I.
dc.contributor.authorCampbell, S.
dc.contributor.authorIsbel, N.
dc.contributor.authorFawcett, J.
dc.contributor.authorFerguson, L. E.
dc.contributor.authorDavis, M.
dc.contributor.authorWhiteman, D. C.
dc.contributor.authorSoyer, H. P.
dc.contributor.authorO'Rourke, P.
dc.contributor.authorGreen, Adèle C
dc.date.accessioned2020-10-06T13:33:47Z
dc.date.available2020-10-06T13:33:47Z
dc.date.issued2020en
dc.identifier.citationMiura K, Way M, Jiyad Z, Marquart L, Plasmeijer EI, Campbell S, et al. Omega-3 fatty acid intake and decreased risk of skin cancer in organ transplant recipients. Eur J Nutr [Internet]. 2020 Sep 9en
dc.identifier.pmid32909136en
dc.identifier.doi10.1007/s00394-020-02378-yen
dc.identifier.urihttp://hdl.handle.net/10541/623337
dc.description.abstractPurpose: Organ transplant recipients have over 100-fold higher risk of developing skin cancer than the general population and are in need of further preventive strategies. We assessed the possible preventive effects of omega-3 polyunsaturated fatty acid (PUFA) intake from food on the two main skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in kidney and liver transplant recipients. Methods: Adult kidney or liver transplant recipients transplanted for at least 1 year and at high risk of skin cancer were recruited from the main transplant hospital in Queensland, 2012-2014 and followed until mid-2016. We estimated their dietary total long-chain omega-3 PUFAs and α-linolenic acid intakes at baseline using a food frequency questionnaire and ranked PUFA intakes as low, medium, or high. Relative risks (RRsadj) of skin cancer adjusted for confounding factors with 95% confidence intervals (CIs) were calculated. Results: There were 449 transplant recipients (mean age, 55 years; 286 (64%) male). During follow-up, 149 (33%) patients developed SCC (median 2/person; range 1-40) and 134 (30%), BCC. Transplant recipients with high total long-chain omega-3 PUFA compared with low intakes showed substantially reduced SCC tumour risk (RRadj 0.33, 95% CI 0.18-0.60), and those with high α-linolenic acid intakes experienced significantly fewer BCCs (RRadj 0.40, 95% CI 0.22-0.74). No other significant associations were seen. Conclusion: Among organ transplant recipients, relatively high intakes of long-chain omega-3 PUFAs and of α-linolenic acid may reduce risks of SCC and BCC, respectively.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1007/s00394-020-02378-yen
dc.titleOmega-3 fatty acid intake and decreased risk of skin cancer in organ transplant recipientsen
dc.typeArticleen
dc.contributor.departmentPopulation Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, Australia.en
dc.identifier.journalEuropean Journal of Nutritionen
dc.description.noteen]


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