Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion
Authors
Moorman, A. V.Schwab, C.
Winterman, E.
Hancock, J.
Castleton, Anna
Cummins, M.
Gibson, B.
Goulden, N.
Kearns, P.
James, B.
Kirkwood, A. A.
Lancaster, D.
Madi, M.
McMillan, A.
Motwani, J.
Norton, A.
O'Marcaigh, A.
Patrick, K.
Bhatnagar, N.
Qureshi, A.
Richardson, D.
Stokley, S.
Taylor, G.
van Delft, F. W.
Moppett, J.
Harrison, C. J.
Samarasinghe, S.
Vora, A.
Affiliation
Wolfson Childhood Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.Issue Date
2020
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Show full item recordAbstract
Patients with an ABL-class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we screened patients with post-induction MRD ≥1% and positive patients (12%) received adjuvant TKI. As the intervention started during UKALL2011, not all eligible patients were screened prospectively. Retrospective screening of eligible patients allowed the outcome of equivalent ABL-class patients who did and did not receive a TKI in first remission to be compared. ABL-class patients who received a TKI in first remission had a reduced risk of relapse/refractory disease: 0% vs. 63% at four years (P = 0·009).Citation
Moorman AV, Schwab C, Winterman E, Hancock J, Castleton A, Cummins M, et al. Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion. Br J Haematol. 2020.Journal
British Journal of HaematologyDOI
10.1111/bjh.17093PubMed ID
32926422Additional Links
https://dx.doi.org/10.1111/bjh.17093Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1111/bjh.17093
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