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dc.contributor.authorQuah, B. L.
dc.contributor.authorDonofrio, C. A.
dc.contributor.authorLa Rosa, S.
dc.contributor.authorBrouland, J. P.
dc.contributor.authorCossu, G.
dc.contributor.authorDjoukhadar, I.
dc.contributor.authorMayers, H.
dc.contributor.authorShenjere, Patrick
dc.contributor.authorPereira, M.
dc.contributor.authorPathmanaban, O. N.
dc.contributor.authorMurtaza, M. O.
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorRoncaroli, F.
dc.contributor.authorKarabatsou, K.
dc.date.accessioned2020-10-06T13:33:42Z
dc.date.available2020-10-06T13:33:42Z
dc.date.issued2020en
dc.identifier.citationQuah BL, Donofrio CA, La Rosa S, Brouland JP, Cossu G, Djoukhadar I, et al. Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm. Virchows Arch. 2020.en
dc.identifier.pmid32918169en
dc.identifier.doi10.1007/s00428-020-02923-4en
dc.identifier.urihttp://hdl.handle.net/10541/623301
dc.description.abstractPrimary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1007/s00428-020-02923-4en
dc.titlePrimary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasmen
dc.typeArticleen
dc.contributor.departmentDepartment of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.en
dc.identifier.journalVirchows Archiven
dc.description.noteen]
refterms.dateFOA2020-10-07T09:44:19Z


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