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    Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm

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    Authors
    Quah, B. L.
    Donofrio, C. A.
    La Rosa, S.
    Brouland, J. P.
    Cossu, G.
    Djoukhadar, I.
    Mayers, H.
    Shenjere, Patrick
    Pereira, M.
    Pathmanaban, O. N.
    Murtaza, M. O.
    Gattamaneni, Rao
    Roncaroli, F.
    Karabatsou, K.
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    Affiliation
    Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
    Issue Date
    2020
    
    Metadata
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    Abstract
    Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.
    Citation
    Quah BL, Donofrio CA, La Rosa S, Brouland JP, Cossu G, Djoukhadar I, et al. Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm. Virchows Arch. 2020.
    Journal
    Virchows Archiv
    URI
    http://hdl.handle.net/10541/623301
    DOI
    10.1007/s00428-020-02923-4
    PubMed ID
    32918169
    Additional Links
    https://dx.doi.org/10.1007/s00428-020-02923-4
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00428-020-02923-4
    Scopus Count
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