Authors
Lamarca, AngelaFrizziero, Melissa
Fulton, Alexander
McNamara, Mairead G
Filobbos, R.
Hubner, Richard A
Wardell, Steve
Valle, Juan W
Affiliation
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom; Division Cancer Sciences, University of Manchester; Manchester, United Kingdom.Issue Date
2020
Metadata
Show full item recordAbstract
Fibrolamellar carcinoma (FLC) is a rare and poorly understood malignancy, which seems to be more prevalent in young patients compared with conventional hepatocellular carcinoma (HCC). Performing prospective clinical trials recruiting patients diagnosed with FLC has proven challenging with scarce data available guiding clinical management. The use of a number of chemotherapy compounds in these patients, including cisplatin, epirubicin, 5-fluorouracil (5-FU) and recombinant interferon ?-2B (IFN-?-2B), has been reported in the literature, mainly in the form of case reports. The most promising systemic therapy tested so far is the combination of 5-FU infusion and 3-weekly IFN-?-2B, based on results from a phase II clinical trial. This article provides an overview of our own experience with this treatment schedule for patients with FLC, confirming its activity and treatment-derived benefit in the real world. Current challenges being faced by healthcare professionals treating patients with advanced FLC are discussed, especially the increasingly limited access to IFN-?-2B, which could compromise the access to an active therapy in the coming future, and the difficulties in the development of new treatment options for advanced FLC. Keywords: 5-FU; 5-fluorouracil treatment; Advanced; Chemotherapy; FLC; Fibrolamellar carcinoma; IFN; Interferon; Systemic therapy.Citation
Lamarca A, Frizziero M, Fulton A, McNamara MG, Filobbos R, Hubner RA, et al. Fibrolamellar carcinoma: Challenging the challenge. European Journal of Cancer. 2020;137:144-7.Journal
European Journal of CancerDOI
10.1016/j.ejca.2020.06.035PubMed ID
32768872Additional Links
https://dx.doi.org/10.1016/j.ejca.2020.06.035Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.ejca.2020.06.035
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