Guidelines for management of urgent symptoms in patients with cholangiocarcinoma and biliary stents or catheters using the modified RAND/UCLA Delphi Process
Authors
Iyer, R. V.Acquisto, S. G.
Bridgewater, J. A.
Choti, M. A.
Hong, T. S.
Kis, B.
Mead, P. A.
Parikh, N. D.
Roberts, L. R.
Roberts, R.
Salem, R.
Sicklick, J. K.
Siegel, R. S.
Whisenant, J. R.
Cherepanov, D.
Broder, M. S.
Valle, Juan W
Affiliation
Roswell Park Cancer Institute, Buffalo, NY 14263, USA.Issue Date
2020
Metadata
Show full item recordAbstract
Background: Patients with cholangiocarcinoma often have indwelling biliary stents or catheters which are prone to obstructions and/or infections; studies show that 20-40% present with fever and/or jaundice requiring urgent treatment in the outpatient setting for which there are no uniform guidelines. The goal was to develop an expert panel consensus on this topic using the modified RAND/UCLA Delphi process to rate treatment appropriateness. Methods: Thirteen expert physicians from relevant specialties, geography, and practice settings were recruited for the panel. Patient scenarios were developed and panelists rated the therapies before and after a face-to-face discussion. The appropriateness of various therapies was rated on a scale from 1-9 and classified as appropriate, inappropriate, or uncertain. Scenarios with greater than 2 (>2) ratings of 1-3 (inappropriate) and greater than 2 (>2) ratings of 7-9 (appropriate) were considered to have disagreement and were not assigned an appropriateness rating. Results: Panelists were from all US regions and the UK (8%) and had practiced for a mean 16.5 years (4-33 years). Panelists rated 480 scenarios before the meeting and re-rated 288 of the clinical scenarios after the meeting. The panelists agreed that ongoing treatment with chemotherapy did not influence decision-making and, therefore, 192 scenarios were excluded from the final list. Disagreement decreased from 37.5% before to 10.4% after the meeting. Consensus on stent/tube manipulation and inpatient antibiotic therapy was obtained and summarized in patients as "appropriate" or "maybe appropriate" based on a patient's bilirubin level at presentation. Conclusions: The Delphi process produced consensus guidelines to fill an unmet need in the urgent management of ascending cholangitis in patients with cholangiocarcinoma.Citation
Iyer RV, Acquisto SG, Bridgewater JA, Choti MA, Hong TS, Kis B, et al. Guidelines for Management of Urgent Symptoms in Patients with Cholangiocarcinoma and Biliary Stents or Catheters Using the Modified RAND/UCLA Delphi Process. Cancers. 2020;12(9):2375.Journal
CancersDOI
10.3390/cancers12092375PubMed ID
32825784Additional Links
https://dx.doi.org/10.3390/cancers12092375Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/cancers12092375