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    Systemic therapy of common tumours in older patients: challenges and opportunities. a young international society of geriatric oncology review paper

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    Authors
    Battisti, N. M. L.
    Liposits, G.
    De Glas, N. A.
    Gomes, Fabio
    Baldini, C.
    Mohile, S.
    Affiliation
    Department of Medicine, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, London, SM2 5PT, UK. nicolo.battisti@rmh.nhs.uk.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Purpose of review: Decision-making for systemic treatments in older patients with cancer is difficult because of concerns for decreased organ function, risk of toxicity, limited life expectancy due to comorbidities and the lack of evidence available to guide its management in this population. Here, we review the data on the role of systemic agents for the treatment of common malignancies in this age group. Recent findings: Evidence on the use of systemic treatments for older patients with cancer is increasing, especially for newer options including immune checkpoint inhibitors and targeted agents that provide comparable benefit in older and younger patients. Nonetheless, the risks for short- and long-term toxicities need to be considered. More research is warranted and represents a unique opportunity to increase the knowledge on cancer treatment for older adults. Healthy, older individuals should be considered for standard systemic treatment options, whereas those at risk based on geriatric assessments require adjusted plans. Geriatric assessments are key for decision-making.
    Citation
    Battisti NML, Liposits G, De Glas NA, Gomes F, Baldini C, Mohile S. Systemic Therapy of Common Tumours in Older Patients: Challenges and Opportunities. A Young International Society of Geriatric Oncology Review Paper. Current Oncology Reports. 2020;22(10):98.
    Journal
    Current Oncology Reports
    URI
    http://hdl.handle.net/10541/623225
    DOI
    10.1007/s11912-020-00958-z
    PubMed ID
    32725503
    Additional Links
    https://dx.doi.org/10.1007/s11912-020-00958-z
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11912-020-00958-z
    Scopus Count
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