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dc.contributor.authorAitkenhead, Adam H
dc.contributor.authorSitch, Peter
dc.contributor.authorRichardson, Jenny C
dc.contributor.authorWinterhalter, Carla
dc.contributor.authorPatel, Imran
dc.contributor.authorMackay, Ranald I
dc.date.accessioned2020-09-16T11:57:51Z
dc.date.available2020-09-16T11:57:51Z
dc.date.issued2020en
dc.identifier.citationAitkenhead AH, Sitch P, Richardson JC, Winterhalter C, Patel I, Mackay RI. Automated Monte-Carlo re-calculation of proton therapy plans using Geant4/Gate: implementation and comparison to plan-specific quality assurance measurements. The British journal of radiology. 2020:20200228.en
dc.identifier.pmid32726141en
dc.identifier.doi10.1259/bjr.20200228en
dc.identifier.urihttp://hdl.handle.net/10541/623221
dc.description.abstractObjectives: Software re-calculation of proton pencil beam scanning plans provides a method of verifying treatment planning system (TPS) dose calculations prior to patient treatment. This study describes the implementation of AutoMC, a Geant4 v10.3.3/Gate v8.1 (Gate-RTion v1.0)-based Monte-Carlo (MC) system for automated plan re-calculation, and presents verification results for 153 patients (730 fields) planned within year one of the proton service at The Christie NHS Foundation Trust. Methods: A MC beam model for a Varian ProBeam delivery system with four range-shifter options (none, 2 cm, 3 cm, 5 cm) was derived from beam commissioning data and implemented in AutoMC. MC and TPS (Varian Eclipse v13.7) calculations of 730 fields in solid-water were compared to physical plan-specific quality assurance (PSQA) measurements acquired using a PTW Octavius 1500XDR array and PTW 31021 Semiflex 3D ion chamber. Results: TPS and MC showed good agreement with array measurements, evaluated using ? analyses at 3%, 3 mm with a 10% lower dose threshold:>94% of fields calculated by the TPS and >99% of fields calculated by MC had ? ? 1 for>95% of measurement points within the plane. TPS and MC also showed good agreement with chamber measurements of absolute dose, with systematic differences of <1.5% for all range-shifter options. Conclusions: Reliable independent verification of the TPS dose calculation is a valuable complement to physical PSQA and may facilitate reduction of the physical PSQA workload alongside a thorough delivery system quality assurance programme. Advances in knowledge: A Gate/Geant4-based MC system is thoroughly validated against an extensive physical PSQA dataset for 730 clinical fields, showing that clinical implementation of MC for PSQA is feasible.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1259/bjr.20200228en
dc.titleAutomated Monte-Carlo re-calculation of proton therapy plans using Geant4/Gate: implementation and comparison to plan-specific quality assurance measurementsen
dc.typeArticleen
dc.contributor.departmentChristie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Radiologyen
dc.description.noteen]


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