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dc.contributor.authorGomes, Fabio
dc.contributor.authorWong, M.
dc.contributor.authorBattisti, N. M. L.
dc.contributor.authorKordbacheh, Tiana
dc.contributor.authorKiderlen, M.
dc.contributor.authorGreystoke, A.
dc.contributor.authorLuciani, A.
dc.date.accessioned2020-08-17T07:21:40Z
dc.date.available2020-08-17T07:21:40Z
dc.date.issued2020en
dc.identifier.citationGomes F, Wong M, Battisti NML, Kordbacheh T, Kiderlen M, Greystoke A, et al. Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper. Br J Cancer. 2020.en
dc.identifier.pmid32694695en
dc.identifier.doi10.1038/s41416-020-0986-4en
dc.identifier.urihttp://hdl.handle.net/10541/623197
dc.description.abstractImmunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41416-020-0986-4en
dc.titleImmunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paperen
dc.typeArticleen
dc.contributor.departmentMedical Oncology, The Christie NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
dc.description.noteen]


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