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    Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper

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    Authors
    Gomes, Fabio
    Wong, M.
    Battisti, N. M. L.
    Kordbacheh, Tiana
    Kiderlen, M.
    Greystoke, A.
    Luciani, A.
    Affiliation
    Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Immunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.
    Citation
    Gomes F, Wong M, Battisti NML, Kordbacheh T, Kiderlen M, Greystoke A, et al. Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper. Br J Cancer. 2020.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/623197
    DOI
    10.1038/s41416-020-0986-4
    PubMed ID
    32694695
    Additional Links
    https://dx.doi.org/10.1038/s41416-020-0986-4
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-020-0986-4
    Scopus Count
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