Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper
Affiliation
Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.Issue Date
2020
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Immunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.Citation
Gomes F, Wong M, Battisti NML, Kordbacheh T, Kiderlen M, Greystoke A, et al. Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper. Br J Cancer. 2020.Journal
British Journal of CancerDOI
10.1038/s41416-020-0986-4PubMed ID
32694695Additional Links
https://dx.doi.org/10.1038/s41416-020-0986-4Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41416-020-0986-4
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