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dc.contributor.authorMarin, J. J. G.
dc.contributor.authorPrete, M. G.
dc.contributor.authorLamarca, Angela
dc.contributor.authorTavolari, S.
dc.contributor.authorLanda-Magdalena, A.
dc.contributor.authorBrandi, G.
dc.contributor.authorSegatto, O.
dc.contributor.authorVogel, A.
dc.contributor.authorMacias, R. I. R.
dc.contributor.authorRodrigues, P. M.
dc.contributor.authorCasta, A.
dc.contributor.authorMertens, J.
dc.contributor.authorRodrigues, C. M. P.
dc.contributor.authorFernandez-Barrena, M. G.
dc.contributor.authorDa Silva Ruivo, A.
dc.contributor.authorMarzioni, M.
dc.contributor.authorMentrasti, G.
dc.contributor.authorAcedo, P.
dc.contributor.authorMunoz-Garrido, P.
dc.contributor.authorCardinale, V.
dc.contributor.authorBanales, J. M.
dc.contributor.authorValle, Juan W
dc.contributor.authorBridgewater, J.
dc.contributor.authorBraconi, C.
dc.date.accessioned2020-08-17T07:21:40Z
dc.date.available2020-08-17T07:21:40Z
dc.date.issued2020en
dc.identifier.citationMarin JJG, Prete MG, Lamarca A, Tavolari S, Landa-Magdalena A, Brandi G, et al. Current and novel therapeutic opportunities for systemic therapy in biliary cancer. Br J Cancer. 2020.en
dc.identifier.pmid32694694en
dc.identifier.doi10.1038/s41416-020-0987-3en
dc.identifier.urihttp://hdl.handle.net/10541/623196
dc.description.abstractBiliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for only a small proportion of patients, current strategies for treating patients with BTCs include chemotherapy, as a single agent or combination regimens, in the adjuvant and palliative setting. Increased characterisation of the molecular landscape of these tumours has facilitated the identification of molecular vulnerabilities, such as IDH mutations and FGFR fusions, that can be exploited for the treatment of BTC patients. Beyond targeted therapies, active research avenues explore the development of novel therapeutics that target the crosstalk between cancer and stroma, the cellular pathways involved in the regulation of cell death, the chemoresistance phenotype and the dysregulation of RNA. In this review, we discuss the therapeutic opportunities currently available in the management of BTC patients, and explore the strategies that can support the implementation of precision oncology in BTCs, including novel molecular targets, liquid biopsies and patient-derived predictive tools.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41416-020-0987-3en
dc.titleCurrent and novel therapeutic opportunities for systemic therapy in biliary canceren
dc.typeArticleen
dc.contributor.departmentIBSAL, University of Salamanca, Salamanca, Spain.en
dc.identifier.journalBritish Journal of Canceren
dc.description.noteen]


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