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    Current and novel therapeutic opportunities for systemic therapy in biliary cancer

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    Authors
    Marin, J. J. G.
    Prete, M. G.
    Lamarca, Angela
    Tavolari, S.
    Landa-Magdalena, A.
    Brandi, G.
    Segatto, O.
    Vogel, A.
    Macias, R. I. R.
    Rodrigues, P. M.
    Casta, A.
    Mertens, J.
    Rodrigues, C. M. P.
    Fernandez-Barrena, M. G.
    Da Silva Ruivo, A.
    Marzioni, M.
    Mentrasti, G.
    Acedo, P.
    Munoz-Garrido, P.
    Cardinale, V.
    Banales, J. M.
    Valle, Juan W
    Bridgewater, J.
    Braconi, C.
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    Affiliation
    IBSAL, University of Salamanca, Salamanca, Spain.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for only a small proportion of patients, current strategies for treating patients with BTCs include chemotherapy, as a single agent or combination regimens, in the adjuvant and palliative setting. Increased characterisation of the molecular landscape of these tumours has facilitated the identification of molecular vulnerabilities, such as IDH mutations and FGFR fusions, that can be exploited for the treatment of BTC patients. Beyond targeted therapies, active research avenues explore the development of novel therapeutics that target the crosstalk between cancer and stroma, the cellular pathways involved in the regulation of cell death, the chemoresistance phenotype and the dysregulation of RNA. In this review, we discuss the therapeutic opportunities currently available in the management of BTC patients, and explore the strategies that can support the implementation of precision oncology in BTCs, including novel molecular targets, liquid biopsies and patient-derived predictive tools.
    Citation
    Marin JJG, Prete MG, Lamarca A, Tavolari S, Landa-Magdalena A, Brandi G, et al. Current and novel therapeutic opportunities for systemic therapy in biliary cancer. Br J Cancer. 2020.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/623196
    DOI
    10.1038/s41416-020-0987-3
    PubMed ID
    32694694
    Additional Links
    https://dx.doi.org/10.1038/s41416-020-0987-3
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-020-0987-3
    Scopus Count
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    All Christie Publications

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