Current and novel therapeutic opportunities for systemic therapy in biliary cancer
Authors
Marin, J. J. G.Prete, M. G.
Lamarca, Angela
Tavolari, S.
Landa-Magdalena, A.
Brandi, G.
Segatto, O.
Vogel, A.
Macias, R. I. R.
Rodrigues, P. M.
Casta, A.
Mertens, J.
Rodrigues, C. M. P.
Fernandez-Barrena, M. G.
Da Silva Ruivo, A.
Marzioni, M.
Mentrasti, G.
Acedo, P.
Munoz-Garrido, P.
Cardinale, V.
Banales, J. M.
Valle, Juan W
Bridgewater, J.
Braconi, C.
Affiliation
IBSAL, University of Salamanca, Salamanca, Spain.Issue Date
2020
Metadata
Show full item recordAbstract
Biliary tract cancers (BTCs) are a group of rare and aggressive malignancies that arise in the biliary tree within and outside the liver. Beyond surgical resection, which is beneficial for only a small proportion of patients, current strategies for treating patients with BTCs include chemotherapy, as a single agent or combination regimens, in the adjuvant and palliative setting. Increased characterisation of the molecular landscape of these tumours has facilitated the identification of molecular vulnerabilities, such as IDH mutations and FGFR fusions, that can be exploited for the treatment of BTC patients. Beyond targeted therapies, active research avenues explore the development of novel therapeutics that target the crosstalk between cancer and stroma, the cellular pathways involved in the regulation of cell death, the chemoresistance phenotype and the dysregulation of RNA. In this review, we discuss the therapeutic opportunities currently available in the management of BTC patients, and explore the strategies that can support the implementation of precision oncology in BTCs, including novel molecular targets, liquid biopsies and patient-derived predictive tools.Citation
Marin JJG, Prete MG, Lamarca A, Tavolari S, Landa-Magdalena A, Brandi G, et al. Current and novel therapeutic opportunities for systemic therapy in biliary cancer. Br J Cancer. 2020.Journal
British Journal of CancerDOI
10.1038/s41416-020-0987-3PubMed ID
32694694Additional Links
https://dx.doi.org/10.1038/s41416-020-0987-3Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41416-020-0987-3
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