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    LncRNAs in non-small-cell lung cancer

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    Authors
    Ginn, Lucy
    Shi, Lei
    La Montagna, Manuela
    Garofalo, Michela
    Affiliation
    Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Manchester
    Issue Date
    2020
    
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    Show full item record
    Abstract
    Lung cancer is associated with a high mortality, with around 1.8 million deaths worldwide in 2018. Non-small-cell lung cancer (NSCLC) accounts for around 85% of cases and, despite improvement in the management of NSCLC, most patients are diagnosed at advanced stage and the five-year survival remains around 15%. This highlights a need to identify novel ways to treat the disease to reduce the burden of NSCLC. Long non-coding RNAs (lncRNAs) are non-coding RNA molecules longer than 200 nucleotides in length which play important roles in gene expression and signaling pathways. Recently, lncRNAs were implicated in cancer, where their expression is dysregulated resulting in aberrant functions. LncRNAs were shown to function as both tumor suppressors and oncogenes in a variety of cancer types. Although there are a few well characterized lncRNAs in NSCLC, many lncRNAs remain un-characterized and their mechanisms of action largely unknown. LncRNAs have success as therapies in neurodegenerative diseases, and having a detailed understanding of their function in NSCLC may guide novel therapeutic approaches and strategies. This review discusses the role of lncRNAs in NSCLC tumorigenesis, highlighting their mechanisms of action and their clinical potential. Keywords: long non-coding RNAs; non-small-cell lung cancer.
    Citation
    Ginn L, Shi L, Montagna M, Garofalo M. LncRNAs in Non-Small-Cell Lung Cancer. Noncoding RNA. 2020;6(3).
    Journal
    Noncoding RNA
    URI
    http://hdl.handle.net/10541/623168
    DOI
    10.3390/ncrna6030025
    PubMed ID
    32629922
    Additional Links
    https://dx.doi.org/10.3390/ncrna6030025
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/ncrna6030025
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