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dc.contributor.authorShenjere, Patrick
dc.contributor.authorChasty, R
dc.contributor.authorChaturvedi, Anshuman
dc.contributor.authorDennis, Michael
dc.contributor.authorWiseman, Daniel H
dc.contributor.authorMenasce, Lia P
dc.contributor.authorOng, A
dc.date.accessioned2020-08-17T07:21:35Z
dc.date.available2020-08-17T07:21:35Z
dc.date.issued2020en
dc.identifier.citationShenjere P, Chasty R, Chaturvedi A, Dennis MW, Ong A, Wiseman DH, et al. E-Cadherin Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms: An Unrecognized Finding and Potential Diagnostic Pitfall. Int J Surg Pathol. 2020:1066896920938130.en
dc.identifier.pmid32608312en
dc.identifier.doi10.1177/1066896920938130en
dc.identifier.urihttp://hdl.handle.net/10541/623158
dc.description.abstractE-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available. Keywords: E-cadherin expression; acute erythroid leukemia; anti-CD123-targeted therapies; blastic plasmacytoid dendritic cell neoplasms; erroneous diagnosis; primary myelofibrosis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1177/1066896920938130en
dc.titleE-Cadherin expression in blastic plasmacytoid dendritic cell neoplasms: an unrecognized finding and potential diagnostic pitfallen
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, The Christie NHS Foundation Trust, Manchesteen
dc.identifier.journalInternational Journal of Surgical Pathologyen
dc.description.noteen]


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