E-Cadherin expression in blastic plasmacytoid dendritic cell neoplasms: an unrecognized finding and potential diagnostic pitfall
Wiseman, Daniel H
Menasce, Lia P
AffiliationDepartment of Histopathology, The Christie NHS Foundation Trust, Mancheste
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AbstractE-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available. Keywords: E-cadherin expression; acute erythroid leukemia; anti-CD123-targeted therapies; blastic plasmacytoid dendritic cell neoplasms; erroneous diagnosis; primary myelofibrosis.
CitationShenjere P, Chasty R, Chaturvedi A, Dennis MW, Ong A, Wiseman DH, et al. E-Cadherin Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms: An Unrecognized Finding and Potential Diagnostic Pitfall. Int J Surg Pathol. 2020:1066896920938130.
JournalInternational Journal of Surgical Pathology
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