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    Tailored functionalized magnetic nanoparticles to target breast cancer cells including cancer stem-like cells

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    Authors
    Lazaro-Carrillo, A
    Calero, M
    Aires, A
    Cortajarena, A
    Simoes, Bruno M
    Latorre, A
    Somoza, A
    Clarke, Robert B
    Miranda, R
    Villanueva, A
    Affiliation
    Departamento de Biologia, Universidad Autonoma de Madrid, Darwin 2, 28049 Madrid, Spain.
    Issue Date
    2020
    
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    Abstract
    Nanotechnology-based approaches hold substantial potential to avoid chemoresistance and minimize side effects. In this work, we have used biocompatible iron oxide magnetic nanoparticles (MNPs) called MF66 and functionalized with the antineoplastic drug doxorubicin (DOX) against MDA-MB-231 cells. Electrostatically functionalized MNPs showed effective uptake and DOX linked to MNPs was more efficiently retained inside the cells than free DOX, leading to cell inactivation by mitotic catastrophe, senescence and apoptosis. Both effects, uptake and cytotoxicity, were demonstrated by different assays and videomicroscopy techniques. Likewise, covalently functionalized MNPs using three different linkers-disulfide (DOX-S-S-Pyr, called MF66-S-S-DOX), imine (DOX-I-Mal, called MF66-I-DOX) or both (DOX-I-S-S-Pyr, called MF66-S-S-I-DOX)-were also analysed. The highest cell death was detected using a linker sensitive to both pH and reducing environment (DOX-I-S-S-Pyr). The greatest success of this study was to detect also their activity against breast cancer stem-like cells (CSC) from MDA-MB-231 and primary breast cancer cells derived from a patient with a similar genetic profile (triple-negative breast cancer). In summary, these nanoformulations are promising tools as therapeutic agent vehicles, due to their ability to produce efficient internalization, drug delivery, and cancer cell inactivation, even in cancer stem-like cells (CSCs) from patients.
    Citation
    Lazaro-Carrillo A, Calero M, Aires A, A LC, Simoes BM, Latorre A, et al. Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. Cancers (Basel). 2020;12(6).
    Journal
    Cancers (Basel)
    URI
    http://hdl.handle.net/10541/623144
    DOI
    10.3390/cancers12061397
    PubMed ID
    32485849
    Additional Links
    https://dx.doi.org/10.3390/cancers12061397
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers12061397
    Scopus Count
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    All Paterson Institute for Cancer Research

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