Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study
AffiliationPopulation Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
MetadataShow full item record
AbstractPurpose: To quantify the prevalence of anxiety or depression (overall; melanoma-related) among people with high-risk primary melanoma, their related use of mental health services and medications, and factors associated with persistent new-onset symptoms across 4 years post-diagnosis. Methods: A longitudinal study of 675 patients newly diagnosed with tumor-stage 1b-4b melanoma. Participants completed the Hospital Anxiety and Depression Scale and answered questions about fear of cancer recurrence, use of medication, and support, serially over 4 years. We identified anxiety and depression trajectories with group-based trajectories models and factors associated with persistent symptoms with logistic regression. Results: At diagnosis, 93 participants (14%) had melanoma-related anxiety or depression, and 136 (20%) were affected by anxiety and/or depression unrelated to melanoma. After 6 months, no more than 27 (5%) reported melanoma-related anxiety or depression at any time, while the point prevalence of anxiety and depression unrelated to melanoma was unchanged (16-21%) among the disease-free. Of 272 participants reporting clinical symptoms of any cause, 34% were taking medication and/or seeing a psychologist or psychiatrist. Of the participants, 11% (n = 59) had new-onset symptoms that persisted; these participants were more likely aged < 70. Conclusions: Melanoma-related anxiety or depression quickly resolves in high-risk primary melanoma patients after melanoma excision, while prevalence of anxiety or depression from other sources remains constant among the disease-free. However, one-in-ten develop new anxiety or depression symptoms (one-in-twenty melanoma-related) that persist. Implications for cancer survivors: Chronic stress has been linked to melanoma progression. Survivors with anxiety and depression should be treated early to improve patient and, potentially, disease outcomes. Keywords: Anxiety; Depression; Distress; Fear of recurrence; Melanoma.
CitationBeesley VL, Hughes MCB, Smithers BM, Khosrotehrani K, Malt MK, von Schuckmann LA, et al. Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study. J Cancer Surviv. 2020.
JournalJournal of Cancer Survivorship
- Variations in supportive care needs of patients after diagnosis of localised cutaneous melanoma: a 2-year follow-up study.
- Authors: Beesley VL, Smithers BM, O'Rourke P, Janda M, Khosrotehrani K, Green AC
- Issue date: 2017 Jan
- Supportive care needs, anxiety, depression and quality of life amongst newly diagnosed patients with localised invasive cutaneous melanoma in Queensland, Australia.
- Authors: Beesley VL, Smithers BM, Khosrotehrani K, Khatun M, O'Rourke P, Hughes MC, Malt MK, Zonta MJ, Bayley GJ, Barbour AP, Brown LJ, D'Arcy J, Allan CP, Green AC
- Issue date: 2015 Jul
- Prevalence and patterns of depression and anxiety in hemodialysis patients: a 12-month prospective study on incident and prevalent populations.
- Authors: Ng HJ, Tan WJ, Mooppil N, Newman S, Griva K
- Issue date: 2015 May
- Depression, anxiety and quality of life in long-term survivors of malignant melanoma: a register-based cohort study.
- Authors: Beutel ME, Fischbeck S, Binder H, Blettner M, Brähler E, Emrich K, Friedrich-Mai P, Imruck BH, Weyer V, Zeissig SR
- Issue date: 2015
- Prevalence and correlates of unmet supportive care needs in patients with resected invasive cutaneous melanoma.
- Authors: Molassiotis A, Brunton L, Hodgetts J, Green AC, Beesley VL, Mulatero C, Newton-Bishop JA, Lorigan P
- Issue date: 2014 Oct