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dc.contributor.authorHo, Adrienne K
dc.contributor.authorCooksley, Timothy J
dc.date.accessioned2020-08-10T08:09:20Z
dc.date.available2020-08-10T08:09:20Z
dc.date.issued2020en
dc.identifier.citationHo AK, Cooksley T. Immune Checkpoint Inhibitor-Mediated Myasthenia Gravis. J Emerg Med. 2020.en
dc.identifier.pmid32565169en
dc.identifier.doi10.1016/j.jemermed.2020.05.004en
dc.identifier.urihttp://hdl.handle.net/10541/623091
dc.description.abstractBackground: Immune checkpoint inhibitors (ICIs) have a wide range of toxicities affecting potentially any organ system stemming from increased activity within the T-cell lineage similar to that observed in autoimmunity. Case report: A 57-year-old man with metastatic papillary renal cell carcinoma treatment with combination ICI therapy presented with a history of rapidly progressive diplopia. Neurological examination revealed bilateral fatigable ptosis and asymmetrical ophthalmoplegia. His clinical findings were in keeping with an immune-mediated myasthenia gravis. He was immediately commenced on 1 mg/kg of intravenous methylprednisolone and pyridostigmine 60 mg 3 times a day. On day 2 of admission he was given 1 g/kg of intravenous immunoglobulins. He made a rapid and full clinical recovery. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Immune-mediated myasthenia gravis is an important toxicity of ICIs. Early recognition and treatment of this presentation may reduce the significant morbidity and mortality associated with it. Keywords: immune checkpoint inhibitors; myasthenia gravis; toxicity.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.jemermed.2020.05.004en
dc.titleImmune checkpoint inhibitor-mediated myasthenia gravisen
dc.typeArticleen
dc.contributor.departmentDepartment of Acute Medicine and Critical Care, The Christie, NHS Foundation Trust, Manchester, United Kingdom.en
dc.identifier.journalJournal of Emergency Medicineen
dc.description.noteen]


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