Affiliation
Department of Acute Medicine and Critical Care, The Christie, Manchester, UK.Issue Date
2020
Metadata
Show full item recordAbstract
Purpose of review: Emergency presentations in patients treated with immune checkpoint inhibitors (ICIs) are a clinical challenge. Clinicians need to be vigilant in diagnosing and treating immune-mediated toxicities. In this review, we consider the approach to managing an acutely unwell patient being treated with ICIs presenting as an emergency. Recent findings: A minority of acutely unwell patients treated with ICIs will have an immune-mediated toxicity. Early recognition and intervention in those with immune-mediated toxicity can reduce the duration and severity of the complications. The use of early immunosuppressive agents along corticosteroid therapy may improve outcomes in patients with life-threatening immune-mediated toxicity. Summary: Individualized management of immune-mediated toxicities is a key challenge for emergency oncology services; this has become part of routine cancer care.Citation
Cooksley T, Stutman R, Klotz A. Emergency management of immune-related toxicity. Curr Opin Oncol. 2020;32(4):274-81.Journal
Current Opinion in OncologyDOI
10.1097/cco.0000000000000635PubMed ID
32541313Additional Links
https://dx.doi.org/10.1097/cco.0000000000000635Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1097/cco.0000000000000635