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    Emergency management of immune-related toxicity

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    Authors
    Cooksley, Timothy J
    Stutman, R
    Klotz, A
    Affiliation
    Department of Acute Medicine and Critical Care, The Christie, Manchester, UK.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Purpose of review: Emergency presentations in patients treated with immune checkpoint inhibitors (ICIs) are a clinical challenge. Clinicians need to be vigilant in diagnosing and treating immune-mediated toxicities. In this review, we consider the approach to managing an acutely unwell patient being treated with ICIs presenting as an emergency. Recent findings: A minority of acutely unwell patients treated with ICIs will have an immune-mediated toxicity. Early recognition and intervention in those with immune-mediated toxicity can reduce the duration and severity of the complications. The use of early immunosuppressive agents along corticosteroid therapy may improve outcomes in patients with life-threatening immune-mediated toxicity. Summary: Individualized management of immune-mediated toxicities is a key challenge for emergency oncology services; this has become part of routine cancer care.
    Citation
    Cooksley T, Stutman R, Klotz A. Emergency management of immune-related toxicity. Curr Opin Oncol. 2020;32(4):274-81.
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/623079
    DOI
    10.1097/cco.0000000000000635
    PubMed ID
    32541313
    Additional Links
    https://dx.doi.org/10.1097/cco.0000000000000635
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1097/cco.0000000000000635
    Scopus Count
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