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    Image guidance in radiation therapy for better cure of cancer

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    Authors
    Gregoire, V
    Guckenberger, M
    Haustermans, K
    Lagendijk, JJW
    Menard, C
    Potter, R
    Slotman, BJ
    Tanderup, K
    Thorwarth, D
    van Herk, Marcel
    Zips, D
    Show allShow less
    Affiliation
    Department of Radiation Oncology, Leon Berard Cancer Center, Lyon, France.
    Issue Date
    2020
    
    Metadata
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    Abstract
    The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs. Radiation doses required to achieve sufficient cancer-cell kill exceed in most clinical situations the dose that can be tolerated by the healthy tissues, especially when large parts of the affected organ are irradiated. High-precision radiation oncology aims at optimizing tumor coverage, while sparing normal tissues. Medical imaging during the preparation phase, as well as in the treatment room for localization of the tumor and directing the beam, referred to as image-guided radiotherapy (IGRT), is the cornerstone of precision radiation oncology. Sophisticated high-resolution real-time IGRT using X-rays, computer tomography, magnetic resonance imaging, or ultrasound, enables delivery of high radiation doses to tumors without significant damage of healthy organs. IGRT is the most convincing success story of radiation oncology over the last decades, and it remains a major driving force of innovation, contributing to the development of personalized oncology, for example, through the use of real-time imaging biomarkers for individualized dose delivery. Keywords: MR-linac; adaptive radiotherapy; brachytherapy; cone-beam CT; image guidance; molecular imaging; radiation; stereotactic radiotherapy.
    Citation
    Gregoire V, Guckenberger M, Haustermans K, Lagendijk JJW, Menard C, Potter R, et al. Image guidance in radiation therapy for better cure of cancer. Mol Oncol. 2020;14(7):1470-91.
    Journal
    Molecular Oncology
    URI
    http://hdl.handle.net/10541/623078
    DOI
    10.1002/1878-0261.12751
    PubMed ID
    32536001
    Additional Links
    https://dx.doi.org/10.1002/1878-0261.12751
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/1878-0261.12751
    Scopus Count
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    All Christie Publications

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