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    Pan-cancer analysis of whole genomes

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    Authors
    Campbell, P. J.
    Getz, G.
    Korbel, J. O.
    Stuart, J. M.
    Jennings, J. L.
    Stein, L. D.
    Perry, M. D.
    Nahal-Bose, H. K.
    Ouellette, B. F. F.
    Li, C. H.
    Rheinbay, E.
    Nielsen, G. P.
    Sgroi, D. C.
    Wu, C. L.
    Faquin, W. C.
    Deshpande, V.
    Boutros, P. C.
    Lazar, A. J.
    Hoadley, K. A.
    Louis, D. N.
    Dursi, L. J.
    Yung, C. K.
    Bailey, M. H.
    Saksena, G.
    Raine, K. M.
    Buchhalter, I.
    Kleinheinz, K.
    Schlesner, M.
    Zhang, J.
    Wang, W.
    Wheeler, D. A.
    Ding, L.
    Simpson, J. T.
    O'Connor, B. D.
    Yakneen, S.
    Ellrott, K.
    Miyoshi, N.
    Butler, A. P.
    Royo, R.
    Shorser, S. I.
    Vazquez, M.
    Rausch, T.
    Tiao, G.
    Waszak, S. M.
    Rodriguez-Martin, B.
    Shringarpure, S.
    Wu, D. Y.
    Demidov, G. M.
    Delaneau, O.
    Hayashi, S.
    Imoto, S.
    Habermann, N.
    Segre, A. V.
    Garrison, E.
    Cafferkey, A.
    Alvarez, E. G.
    Heredia-Genestar, J. M.
    Muyas, F.
    Drechsel, O.
    Bruzos, A. L.
    Temes, J.
    Zamora, J.
    Baez-Ortega, A.
    Kim, H. L.
    Mashl, R. J.
    Ye, K.
    DiBiase, A.
    Huang, K. L.
    Letunic, I.
    McLellan, M. D.
    Newhouse, S. J.
    Shmaya, T.
    Kumar, S.
    Wedge, D. C.
    Wright, M. H.
    Yellapantula, V. D.
    Gerstein, M.
    Khurana, E.
    Marques-Bonet, T.
    Navarro, A.
    Bustamante, C. D.
    Siebert, R.
    Nakagawa, H.
    Easton, D. F.
    Ossowski, S.
    Tubio, J. M. C.
    De La Vega, F. M.
    Estivill, X.
    Yuen, D.
    Mihaiescu, G. L.
    Omberg, L.
    Ferretti, V.
    Sabarinathan, R.
    Pich, O.
    Gonzalez-Perez, A.
    Weiner, A. T.
    Fittall, M. W.
    Demeulemeester, J.
    Tarabichi, M.
    Roberts, N. D.
    Van Loo, P.
    Cort's-Ciriano, I.
    Urban, L.
    Park, P.
    Bin, Z.
    Pitk'nen, E.
    Li, Y.
    Saini, N.
    Klimczak, L. J.
    Weischenfeldt, J.
    Sidiropoulos, N.
    Alexandrov, L. B.
    Rabionet, R.
    Escaramis, G.
    Bosio, M.
    Holik, A. Z.
    Susak, H.
    Prasad, A.
    Erkek, S.
    Calabrese, C.
    Raeder, B.
    Harrington, E.
    Mayes, S.
    Turner, D.
    Juul, S.
    Roberts, S. A.
    Song, L.
    Koster, R.
    Mirabello, L.
    Hua, X.
    Tanskanen, T. J.
    Tojo, M.
    Chen, J.
    Aaltonen, L. A.
    R'tsch, G.
    Schwarz, R. F.
    Butte, A. J.
    Brazma, A.
    Chanock, S. J.
    Chatterjee, N.
    Stegle, O.
    Harismendy, O.
    Bova, G. S.
    Gordenin, D. A.
    Haan, D.
    Sieverling, L.
    Feuerbach, L.
    Chalmers, D.
    Joly, Y.
    Knoppers, B.
    Moln'r-G'bor, F.
    Phillips, M.
    Thorogood, A.
    Townend, D.
    Goldman, M.
    Fonseca, N. A.
    Xiang, Q.
    Craft, B.
    Munoz, A
    Petryszak, R.
    Al-Shahrour, F.
    Keays, M.
    Haussler, D.
    Weinstein, J.
    Huber, W.
    Valencia, A.
    Papatheodorou, I.
    Zhu, J.
    Fan, Y.
    Torrents, D.
    Bieg, M.
    Chen, K.
    Chong, Z.
    Cibulskis, K.
    Eils, R.
    Fulton, R. S.
    Gelpi, J. L.
    Gonzalez, S.
    Gut, I. G.
    Hach, F.
    Heinold, M.
    Hu, T.
    Huang, V.
    Hutter, B.
    J'ger, N.
    Jung, J.
    Kumar, Y.
    Lalansingh, C.
    Leshchiner, I.
    Livitz, D.
    Ma, E. Z.
    Maruvka, Y. E.
    Milovanovic, A.
    Nielsen, M. M.
    Paramasivam, N.
    Pedersen, J. S.
    Puiggr's, M.
    Sahinalp, S. C.
    Sarrafi, I.
    Stewart, C.
    Stobbe, M. D.
    Wala, J. A.
    Wang, J.
    Wendl, M.
    Werner, J.
    Wu, Z.
    Xue, H.
    Yamaguchi, T. N.
    Yellapantula, V.
    Davis-Dusenbery, B. N.
    Grossman, R. L.
    Kim, Y.
    Heinold, M. C.
    Hinton, J.
    Jones, D. R.
    Menzies, A.
    Stebbings, L.
    Hess, J. M.
    Rosenberg, M.
    Dunford, A. J.
    Gupta, M.
    Imielinski, M.
    Meyerson, M.
    Beroukhim, R.
    Reimand, J.
    Dhingra, P.
    Favero, F.
    Dentro, S.
    Wintersinger, J.
    Rudneva, V.
    Park, J. W.
    Hong, E. P.
    Heo, S. G.
    Kahles, A.
    Kjong-Van, L.
    Soulette, C. M.
    Shiraishi, Y.
    Liu, F.
    He, Y.
    Demircioglu, D.
    Davidson, N. R.
    Greger, L.
    Li, S.
    Liu, D.
    Stark, S. G.
    Zhang, F.
    Amin, S. B.
    Bailey, P.
    Chateigner, A.
    Frenkel-Morgenstern, M.
    Hou, Y.
    Huska, M. R.
    Kilpinen, H.
    Lamaze, F. C.
    Li, C.
    Li, X.
    Li, X.
    Liu, X.
    Marin, M. G.
    Markowski, J.
    Nandi, T.
    Ojesina, A. I.
    Pan-Hammarstr'm, Q.
    Park, P. J.
    Pedamallu, C. S.
    Su, H.
    Tan, P.
    Teh, B.
    Wang, J.
    Xiong, H.
    Ye, C.
    Yung, C.
    Zhang, X. Q.
    Zheng, L. T.
    Zhu, S.
    Awadalla, P.
    Creighton, C. J.
    Wu, K.
    Yang, H. M.
    G'ke, J.
    Zhang, Z.
    Brooks, A. N.
    Martincorena, I.
    Rubio-Perez, C.
    Juul, M.
    Schumacher, S.
    Shapira, O.
    Tamborero, D.
    Mularoni, L.
    Hornshoj, H.
    Deu-Pons, J.
    Mui'os, F.
    Bertl, J.
    Guo, Q.
    Bazant, W.
    Barrera, E.
    Al-Sedairy, S. T.
    Aretz, A.
    Bell, C.
    Betancourt, M.
    Buchholz, C.
    Calvo, F.
    Chomienne, C.
    Dunn, M.
    Edmonds, S.
    Green, E.
    Gupta, S.
    Hutter, C. M.
    Jegalian, K.
    Jones, N.
    Lu, Y. Y.
    Nakagama, H.
    Nettekoven, G.
    Planko, L.
    Scott, D.
    Shibata, T.
    Shimizu, K.
    Stratton, M. R.
    Yugawa, T.
    Tortora, G.
    VijayRaghavan, K.
    Zenklusen, J. C.
    Knoppers, B. M.
    Aminou, B.
    Bartolome, J.
    Boroevich, K. A.
    Boyce, R.
    Buchanan, A.
    Byrne, N. J.
    Chen, Z.
    Cho, S.
    Choi, W.
    Clapham, P.
    Dow, M. T.
    Dursi, L. J.
    Eils, J.
    Farcas, C.
    Fayzullaev, N.
    Flicek, P.
    Heath, A. P.
    Hofmann, O.
    Hong, J. H.
    Hudson, T. J.
    Hubschmann D
    Ivkovic, S.
    Jeon, S. H.
    Jiao, W.
    Kabbe, R.
    Kerssemakers, J. N. A.
    Kim, H.
    Kim, J.
    Koscher, M.
    Koures, A.
    Kovacevic, M.
    Lawerenz, C.
    Liu, J.
    Mijalkovic, S.
    Mijalkovic-Lazic, A. M.
    Miyano, S.
    Nastic, M.
    Nicholson, J.
    Ocana, D.
    Ohi, K.
    Ohno-Machado, L.
    Pihl, T. D.
    Prinz, M.
    Radovic, P.
    Short, C.
    Sofia, H. J.
    Spring, J.
    Struck, A. J.
    Tijanic, N.
    Vicente, D.
    Wang, Z.
    Williams, A.
    Woo, Y.
    Wright, A. J.
    Yang, L.
    Hamilton, M. P.
    Johnson, T. A.
    Kahraman, A.
    Kellis, M.
    Polak, P.
    Sallari, R.
    Sinnott-Armstrong, N.
    von Mering, C.
    Beltran, S.
    Gerhard, D. S.
    Gut, M.
    Trotta, J. R.
    Whalley, J. P.
    Niu, B.
    Espiritu, S. M. G.
    Gao, S.
    Huang, Y.
    Lalansingh, C. M.
    Teague, J. W.
    Wendl, M. C.
    Abascal, F.
    Bader, G. D.
    Bandopadhayay, P.
    Barenboim, J.
    Brunak, S.
    Fita, J. C.
    Chakravarty, D.
    Chan, C. W. Y.
    Choi, J. K.
    Diamanti, K.
    Fink, J. L.
    Frigola, J.
    Gambacorti-Passerini, C.
    Garsed, D. W.
    Haradhvala, N. J.
    Harmanci, A. O.
    Helmy, M.
    Herrmann, C.
    Hobolth, A.
    Hodzic, E.
    Hong, C.
    Isaev, K.
    Izarzugaza, J. M. G.
    Johnson, R.
    Juul, R. I.
    Kim, J.
    Kim, J. K.
    Komorowski, J.
    Lanz's, A.
    Larsson, E.
    Lee, D.
    Li, S.
    Li, X.
    Lin, Z.
    Liu, E. M.
    Lochovsky, L.
    Lou, S.
    Madsen, T.
    Marchal, K.
    Fundichely, A. M.
    McGillivray, P. D.
    Meyerson, W.
    Paczkowska, M.
    Park, K.
    Park, K.
    Pons, T.
    Pulido-Tamayo, S.
    Salazar, I. R.
    Reyna, M. A.
    Rubin, M. A.
    Salichos, L.
    Sander, C.
    Schumacher, S. E.
    Shackleton, M.
    Shen, C.
    Shrestha, R.
    Shuai, S.
    Tsunoda, T.
    Umer, H. M.
    Uusk'la-Reimand, L.
    Verbeke, L. P. C.
    Wadelius, C.
    Wadi, L.
    Warrell, J.
    Wu, G.
    Yu, J.
    Zhang, J.
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    Zhang, Y.
    Zhao, Z.
    Zou, L.
    Lawrence, M. S.
    Raphael, B. J.
    Bailey, P. J.
    Craft, D.
    Goldman, M. J.
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    Kretzmer, H.
    Laird, P. W.
    Martin-Subero, J. I.
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    Sipahimalani, P.
    Skelly, T. J.
    McCune, K. S.
    Socci, N. D.
    Soloway, M. G.
    Sood, A. K.
    Tam, A.
    Tan, D.
    Tarnuzzer, R.
    Thiessen, N.
    Thompson, R. H.
    Thorne, L. B.
    Tsao, M.
    Umbricht, C.
    Van Den Berg, D. J.
    Van Meir, E. G.
    Veluvolu, U.
    Voet, D.
    Wang, L.
    Weinberger, P.
    Weisenberger, D. J.
    Wigle, D.
    Wilkerson, M. D.
    Wilson, R. K.
    Winterhoff, B.
    Wiznerowicz, M.
    Wong, T.
    Wong, W.
    Xi, L.
    Yau, C.
    Zhang, H.
    Zhang, H.
    Zhang, J.
    Pineiro-Yannez, E
    Fullgrabe, A
    Show allShow less
    Affiliation
    Wellcome Sanger Institute, Hinxton, UK
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Fibrosis and fat replacement in skeletal muscle are major complications that lead to a loss of mobility in chronic muscle disorders, such as muscular dystrophy. However, the in vivo properties of adipogenic stem and precursor cells remain unclear, mainly due to the high cell heterogeneity in skeletal muscles. Here, we use single-cell RNA sequencing to decomplexify interstitial cell populations in healthy and dystrophic skeletal muscles. We identify an interstitial CD142-positive cell population in mice and humans that is responsible for the inhibition of adipogenesis through GDF10 secretion. Furthermore, we show that the interstitial cell composition is completely altered in muscular dystrophy, with a near absence of CD142-positive cells. The identification of these adipo-regulatory cells in the skeletal muscle aids our understanding of the aberrant fat deposition in muscular dystrophy, paving the way for treatments that could counteract degeneration in patients with muscular dystrophy.
    Citation
    P. J. Campbell, G. Getz, J. O. Korbel et al. Pan-cancer analysis of whole genomes. Nature. 2020;578(7793):82-+
    Journal
    Nature
    URI
    http://hdl.handle.net/10541/623059
    DOI
    10.1038/s41586-020-1969-6
    PubMed ID
    32025007
    Additional Links
    https://dx.doi.org/10.1038/s41586-020-1969-6
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41586-020-1969-6
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

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