Yttrium-90 radioembolization in intrahepatic cholangiocarcinoma: a multicenter retrospective analysis
dc.contributor.author | Buettner, S. | |
dc.contributor.author | Braat, A. | |
dc.contributor.author | Margonis, G. A. | |
dc.contributor.author | Brown, D. B. | |
dc.contributor.author | Taylor, K. B. | |
dc.contributor.author | Borgmann, A. J. | |
dc.contributor.author | Kappadath, S. C. | |
dc.contributor.author | Mahvash, A. | |
dc.contributor.author | JNM, I. J. | |
dc.contributor.author | Weiss, M. J. | |
dc.contributor.author | Lamarca, Angela | |
dc.contributor.author | Bell, Jon | |
dc.contributor.author | Valle, Juan W | |
dc.contributor.author | Hagendoorn, J. | |
dc.contributor.author | Koerkamp, B. G. | |
dc.contributor.author | Sze, D. Y. | |
dc.contributor.author | Lam, M. | |
dc.date.accessioned | 2020-06-16T11:03:16Z | |
dc.date.available | 2020-06-16T11:03:16Z | |
dc.date.issued | 2020 | en |
dc.identifier.citation | S. Buettner, A. Braat, G. A. Margonis et al. Yttrium-90 Radioembolization in Intrahepatic Cholangiocarcinoma: A Multicenter Retrospective Analysis. J Vasc Interv Radiol. 2020. | en |
dc.identifier.pmid | 32473757 | en |
dc.identifier.doi | 10.1016/j.jvir.2020.02.008 | en |
dc.identifier.uri | http://hdl.handle.net/10541/623034 | |
dc.description.abstract | PURPOSE: To report outcomes of yttrium-90 ((90)Y) radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC). MATERIALS AND METHODS: Retrospective review was performed of 115 patients at 6 tertiary care centers; 92 were treated with resin microspheres (80%), 22 were treated with glass microspheres (19%), and 1 was treated with both. Postintervention outcomes were compared between groups with chi(2) tests. Survival after diagnosis and after treatment was assessed by Kaplan-Meier method. RESULTS: Grade 3 laboratory toxicity was observed in 4 patients (4%); no difference in toxicity profile between resin and glass microspheres was observed (P = .350). Clinical toxicity per Society of Interventional Radiology criteria was noted in 29 patients (25%). Partial response per Response Evaluation Criteria In Solid Tumors 1.1 was noted in 25% of patients who underwent embolization with glass microspheres and 3% of patients who were treated with resin microspheres (P = .008). Median overall survival (OS) from first diagnosis was 29 months (95% confidence interval [CI], 21-37 mo) for all patients, and 1-, 3-, and 5-year OS rates were 85%, 31%, and 8%, respectively. Median OS after treatment was 11 months (95% CI, 8-13 mo), and 1- and 3-year OS rates were 44% and 4%, respectively. These estimates were not significantly different between resin and glass microspheres (P = .730 and P = .475, respectively). Five patients were able to undergo curative-intent resection after (90)Y radioembolization (4%). CONCLUSIONS: This study provides observational data of treatment outcomes after (90)Y radioembolization in patients with unresectable ICC. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1016/j.jvir.2020.02.008 | en |
dc.title | Yttrium-90 radioembolization in intrahepatic cholangiocarcinoma: a multicenter retrospective analysis | en |
dc.type | Article | en |
dc.contributor.department | Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands. | en |
dc.identifier.journal | Journal of Vascular and Interventional Radiology | en |
dc.description.note | en] |