Yttrium-90 radioembolization in intrahepatic cholangiocarcinoma: a multicenter retrospective analysis
Margonis, G. A.
Brown, D. B.
Taylor, K. B.
Borgmann, A. J.
Kappadath, S. C.
JNM, I. J.
Weiss, M. J.
Valle, Juan W
Koerkamp, B. G.
Sze, D. Y.
AffiliationDepartment of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
MetadataShow full item record
AbstractPURPOSE: To report outcomes of yttrium-90 ((90)Y) radioembolization in patients with unresectable intrahepatic cholangiocarcinoma (ICC). MATERIALS AND METHODS: Retrospective review was performed of 115 patients at 6 tertiary care centers; 92 were treated with resin microspheres (80%), 22 were treated with glass microspheres (19%), and 1 was treated with both. Postintervention outcomes were compared between groups with chi(2) tests. Survival after diagnosis and after treatment was assessed by Kaplan-Meier method. RESULTS: Grade 3 laboratory toxicity was observed in 4 patients (4%); no difference in toxicity profile between resin and glass microspheres was observed (P = .350). Clinical toxicity per Society of Interventional Radiology criteria was noted in 29 patients (25%). Partial response per Response Evaluation Criteria In Solid Tumors 1.1 was noted in 25% of patients who underwent embolization with glass microspheres and 3% of patients who were treated with resin microspheres (P = .008). Median overall survival (OS) from first diagnosis was 29 months (95% confidence interval [CI], 21-37 mo) for all patients, and 1-, 3-, and 5-year OS rates were 85%, 31%, and 8%, respectively. Median OS after treatment was 11 months (95% CI, 8-13 mo), and 1- and 3-year OS rates were 44% and 4%, respectively. These estimates were not significantly different between resin and glass microspheres (P = .730 and P = .475, respectively). Five patients were able to undergo curative-intent resection after (90)Y radioembolization (4%). CONCLUSIONS: This study provides observational data of treatment outcomes after (90)Y radioembolization in patients with unresectable ICC.
CitationS. Buettner, A. Braat, G. A. Margonis et al. Yttrium-90 Radioembolization in Intrahepatic Cholangiocarcinoma: A Multicenter Retrospective Analysis. J Vasc Interv Radiol. 2020.
JournalJournal of Vascular and Interventional Radiology
- Intrahepatic Cholangiocarcinoma Treated with Transarterial Yttrium-90 Glass Microsphere Radioembolization: Results of a Single Institution Retrospective Study.
- Authors: Gangi A, Shah J, Hatfield N, Smith J, Sweeney J, Choi J, El-Haddad G, Biebel B, Parikh N, Arslan B, Hoffe SE, Frakes JM, Springett GM, Anaya DA, Malafa M, Chen DT, Chen Y, Kim RD, Shridhar R, Kis B
- Issue date: 2018 Aug
- Modified response evaluation criteria in solid tumors and European Association for The Study of the Liver criteria using delayed-phase imaging at an early time point predict survival in patients with unresectable intrahepatic cholangiocarcinoma following yttrium-90 radioembolization.
- Authors: Camacho JC, Kokabi N, Xing M, Prajapati HJ, El-Rayes B, Kim HS
- Issue date: 2014 Feb
- Outcomes of Yttrium-90 Radioembolization for Unresectable Combined Biphenotypic Hepatocellular-Cholangiocarcinoma.
- Authors: Malone CD, Gibby W, Tsai R, Kim SK, Lancia S, Akinwande O, Ramaswamy RS
- Issue date: 2020 May
- Yttrium-90 Transarterial Radioembolization for Chemotherapy-Refractory Intrahepatic Cholangiocarcinoma: A Prospective, Observational Study.
- Authors: White J, Carolan-Rees G, Dale M, Patrick HE, See TC, Bell JK, Manas DM, Crellin A, Slevin NJ, Sharma RA
- Issue date: 2019 Aug
- Yttrium-90 microsphere radioembolization in unresectable intrahepatic cholangiocarcinoma.
- Authors: Mosconi C, Cappelli A, Ascanio S, Pettinari I, Modestino F, Renzulli M, Galaverni MC, Cucchetti A, Gramenzi A, Pettinato C, Golfieri R
- Issue date: 2017 Jun