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    Once daily versus twice-daily radiotherapy in the management of limited disease small cell lung cancer - Decision criteria in routine practice

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    Authors
    Glatzer, M.
    Faivre-Finn, Corinne
    De Ruysscher, D
    Widder, J.
    Van Houtte, P.
    Troost, E. G. C.
    Dahele, M. R.
    Slotman, B. J.
    Ramella, S.
    Pottgen, C.
    Peeters, S. T. H.
    Nestle, U.
    McDonald, F.
    Le Pechoux, C.
    Dziadziuszko, R.
    Belderbos, J.
    Putora, P. M.
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    Affiliation
    Department of Radiation Oncology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: In limited disease small cell lung cancer (LD-SCLC), the CONVERT trial has not demonstrated superiority of once-daily (QD) radiotherapy (66 Gy) over twice-daily (BID) radiotherapy (45 Gy). We explored the factors influencing the selection between QD and BID regimens. METHODS: Thirteen experienced European thoracic radiation oncologists as selected by the European Society for Therapeutic Radiation Oncology (ESTRO) were asked to describe their strategies in the management of LD-SCLC. Treatment strategies were subsequently converted into decision trees and analysed for agreement and discrepancies. RESULTS: Logistic reasons, patients performance status and radiotherapy dose constraints were the three major decision criteria used by most experts in decision making. The use of QD and BID regimens was balanced among European experts, but there was a trend towards the BID regimen for fit patients able to travel twice a day to the radiotherapy site. CONCLUSION: BID and QD radiotherapy are both accepted regimens among experts and the decision is influenced by pragmatic factors such as availability of transportation.
    Citation
    M. Glatzer, C. Faivre-Finn, D. De Ruysscher et al. Once daily versus twice-daily radiotherapy in the management of limited disease small cell lung cancer - Decision criteria in routine practice. Radiother Oncol. 2020.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/623028
    DOI
    10.1016/j.radonc.2020.05.004
    PubMed ID
    32447035
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2020.05.004
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2020.05.004
    Scopus Count
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