D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
Authors
de Chiara CHomsak M
Prosser, GA
Purkiss AG
Tate EW
de Carvalho LPS
Douglas, HL
Garza-garcia, A
Kelly, G
Affiliation
Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, UK.Issue Date
2020
Metadata
Show full item recordCitation
Dunnett-Kane V, Burkitt-Wright E, Blackhall FH, Malliri A, Evans G, Lindsay CR. Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts. Ann Oncol. 2020.Journal
Nature Chemical BiologyDOI
10.1038/s41589-020-0498-9PubMed ID
32203411Additional Links
https://dx.doi.org/10.1038/s41589-020-0498-9Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41589-020-0498-9
Scopus Count
Collections
Related articles
- Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.
- Authors: Prosser GA, de Carvalho LP
- Issue date: 2013 Feb
- Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2).
- Authors: Tassoni R, van der Aart LT, Ubbink M, van Wezel GP, Pannu NS
- Issue date: 2017 Jan 29
- Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
- Authors: Nakatani Y, Opel-Reading HK, Merker M, Machado D, Andres S, Kumar SS, Moradigaravand D, Coll F, Perdigão J, Portugal I, Schön T, Nair D, Devi KRU, Kohl TA, Beckert P, Clark TG, Maphalala G, Khumalo D, Diel R, Klaos K, Aung HL, Cook GM, Parkhill J, Peacock SJ, Swaminathan S, Viveiros M, Niemann S, Krause KL, Köser CU
- Issue date: 2017 Dec
- Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice.
- Authors: Awasthy D, Bharath S, Subbulakshmi V, Sharma U
- Issue date: 2012 Feb
- Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine.
- Authors: Noda M, Kawahara Y, Ichikawa A, Matoba Y, Matsuo H, Lee DG, Kumagai T, Sugiyama M
- Issue date: 2004 Oct 29