Long-term deaths from melanoma according to tumor thickness at diagnosis
Green, Adèle C
AffiliationCancer Council Queensland, Brisbane, Queensland, Australia
MetadataShow full item record
AbstractThere is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Australia) diagnosed with a single invasive melanoma (International Classification of Diseases for Oncology, third revision [ICD-O-3], C44, Morphology 872-879) between 1987 and 2011, including 11,883 diagnosed between 1987 and 1996, with up to 20 years follow-up (to December 2016). The 20-year case fatality increased by thickness, with the percentage of melanoma deaths within 20 years of diagnosis being up to 4.8% for melanomas with measured thickness <0.80 mm, 10.6% for tumors 0.8 to <1.0 mm and generally more than 30% for melanomas measuring 3 mm and more. For melanomas <1.0 mm, most deaths occurred between 5 and 20 years after diagnosis, whereas for thicker melanomas the reverse was true with most deaths occurring within the first 5 years. Five-year case fatality decreased over successive calendar time periods for melanomas <1.0 mm, but not for melanomas ≥1.0 mm. These findings demonstrate that the time course for fatal melanomas varies markedly according to tumor thickness at diagnosis. Improved understanding of the patient factors and characteristics of melanomas, in addition to tumor thickness, which increase the likelihood of progression, is needed to guide clinical diagnosis, communication with patients and ongoing surveillance pathways of patients with potentially fatal lesions.
CitationBaade PD, Whiteman DC, Janda M, Cust AE, Neale RE, Smithers BM, et al. Long-term deaths from melanoma according to tumor thickness at diagnosis. Int J Cancer. 2020.
JournalInternational Journal of Cancer
- Clinicopathological factors associated with death from thin (≤ 1·00 mm) melanoma.
- Authors: Claeson M, Baade P, Brown S, Soyer HP, Smithers BM, Green AC, Whiteman DC, Khosrotehrani K
- Issue date: 2020 Apr
- Population-based 20-year survival among people diagnosed with thin melanomas in Queensland, Australia.
- Authors: Green AC, Baade P, Coory M, Aitken JF, Smithers M
- Issue date: 2012 May 1
- Ten-Year Survival after Multiple Invasive Melanomas Is Worse than after a Single Melanoma: a Population-Based Study.
- Authors: Youlden DR, Baade PD, Soyer HP, Youl PH, Kimlin MG, Aitken JF, Green AC, Khosrotehrani K
- Issue date: 2016 Nov
- The relationship between melanoma thickness and time to diagnosis in a large population-based study.
- Authors: Baade PD, English DR, Youl PH, McPherson M, Elwood JM, Aitken JF
- Issue date: 2006 Nov
- Distribution of subsequent primary invasive melanomas following a first primary invasive or in situ melanoma Queensland, Australia, 1982-2010.
- Authors: Youlden DR, Youl PH, Soyer HP, Aitken JF, Baade PD
- Issue date: 2014 May