Use of antidepressants and risk of cutaneous melanoma: a prospective registry-based case-control study
Green, Adèle C
AffiliationDepartment of Research, Cancer Registry of Norway, Oslo, Norway
MetadataShow full item record
AbstractPURPOSE: Melanoma is the cancer with the most rapidly rising incidence rate in Norway. Although exposure to ultraviolet radiation (UVR) is the major environmental risk factor, other factors may also contribute. Antidepressants have cancer inhibiting and promoting side effects, and their prescription rates have increased in parallel with melanoma incidence. Thus, we aimed to prospectively examine the association between use of antidepressants and melanoma by using nation-wide data from the Cancer Registry of Norway, the National Registry, the Norwegian Prescription Database and the Medical Birth Registry of Norway. PATIENT AND METHODS: All cases aged 18-85 with a primary cutaneous invasive melanoma diagnosed during 2007-2015 (n=12,099) were matched to population controls 1:10 (n=118,467) by sex and year of birth using risk-set sampling. We obtained information on prescribed antidepressants and other potentially confounding drug use (2004-2015). Conditional logistic regression was used to estimate adjusted rate ratios (RRs) and 95% confidence intervals (CIs) for the association between overall and class-specific use of antidepressants and incident melanoma. RESULTS: Compared with ≤1 prescription, ≥8 prescriptions of antidepressants overall were negatively associated with melanoma (RR 0.81 CI 0.75-0.87). Class-specific analyses showed decreased RRs for selective serotonin reuptake inhibitors (RR 0.82 CI 0.73-0.93) and mixed antidepressants (RR 0.77 CI 0.69-0.86). The negative association was found for both sexes, age ≥50 years, residential regions with medium and highest ambient UVR exposure, all histological subtypes, trunk, upper and lower limb sites and local disease. CONCLUSION: Use of antidepressants was associated with decreased risk of melanoma. There are at least two possible explanations for our results; cancer-inhibiting actions induced by the drug and less UVR exposure among the most frequent users of antidepressants.
CitationBerge LAM, Andreassen BK, Stenehjem JS, Heir T, Furu K, Juzeniene A, et al. Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study. Clin Epidemiol. 2020;12:193-202.
- Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study.
- Authors: Berge LAM, Andreassen BK, Stenehjem JS, Larsen IK, Furu K, Juzeniene A, Roscher I, Heir T, Green A, Veierød MB, Robsahm TE
- Issue date: 2019 Feb 20
- Increased risk of hip fracture among older people using antidepressant drugs: data from the Norwegian Prescription Database and the Norwegian Hip Fracture Registry.
- Authors: Bakken MS, Engeland A, Engesæter LB, Ranhoff AH, Hunskaar S, Ruths S
- Issue date: 2013 Jul
- Time trends in incidence of cutaneous melanoma by detailed anatomical location and patterns of ultraviolet radiation exposure: a retrospective population-based study.
- Authors: Gordon D, Gillgren P, Eloranta S, Olsson H, Gordon M, Hansson J, Smedby KE
- Issue date: 2015 Aug
- Use of antidepressants and risk of epithelial ovarian cancer.
- Authors: Mørch LS, Dehlendorff C, Baandrup L, Friis S, Kjaer SK
- Issue date: 2017 Dec 1
- Sex differences in rising trends of cutaneous malignant melanoma in Norway, 1954-2008.
- Authors: Robsahm TE, Bergva G, Hestvik UE, Møller B
- Issue date: 2013 Feb