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dc.contributor.authorEccles, Cynthia L
dc.contributor.authorAdair, SG
dc.contributor.authorBower, L
dc.contributor.authorHafeez, S
dc.contributor.authorHerbert, T
dc.contributor.authorHunt, A
dc.contributor.authorMcNair, HA
dc.contributor.authorOfuya, M
dc.contributor.authorOelfke, U
dc.contributor.authorNill, S
dc.contributor.authorHuddart, RA
dc.date.accessioned2020-03-27T09:28:02Z
dc.date.available2020-03-27T09:28:02Z
dc.date.issued2019en
dc.identifier.citationEccles CL, Adair Smith G, Bower L, Hafeez S, Herbert T, Hunt A, et al. Magnetic resonance imaging sequence evaluation of an MR Linac system; early clinical experience. Technical innovations & patient support in radiation oncology. 2019;12:56-63.en
dc.identifier.pmid32095556en
dc.identifier.doi10.1016/j.tipsro.2019.11.004en
dc.identifier.urihttp://hdl.handle.net/10541/622835
dc.description.abstractOBJECTIVES: To systematically identify the preferred magnetic resonance imaging (MRI) sequences following volunteer imaging on a 1.5 Tesla (T) MR-Linear Accelerator (MR Linac) for future protocol development. METHODS: Non-patient volunteers were recruited to a Research and Ethics committee approved prospective MR-only imaging study on a 1.5T MR Linac system. Volunteers attended 1-3 imaging sessions that included a combination of mDixon, T1w, T2w sequences using 2-dimensional (2D) and 3-dimensional (3D) acquisitions. Each sequence was acquired over 2-7 minutes and reviewed by a panel of 3 observers to evaluate image quality using a visual grading analysis based on a 4-point Likert scale. Sequences were acquired and modified iteratively until deemed fit for purpose (online image matching or re-planning) and all observers agreed they were suitable in 3 volunteers. RESULTS: 26 volunteers underwent 31 imaging sessions of six general anatomical regions. Images were acquired in one or two of six general anatomical regions: male pelvis (n = 9), female pelvis (n = 4), chestwall/breast (n = 5), lung/oesophagus (n = 5), abdomen (n = 3) and head and neck (n = 5). Images were acquired using a pre-defined exam-card that on average, included six sequences (range 2-10), with a maximum scan time of approximately one hour. The majority of observers preferred T2-weighted sequences. The thorax teams were the only groups to prefer T1-weighted imaging. CONCLUSIONS: An iterative process identified sequence agreement in all anatomical regions. These sequences will now be evaluated in patient volunteers. ADVANCES IN KNOWLEDGE: This manuscript is the first publication sharing the results of the first systematic selection of MRI sequences for use in on-board MRI-guided radiotherapy by end-users (therapeutic radiographers and clinical oncologists) in healthy volunteers.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.tipsro.2019.11.004en
dc.titleMagnetic resonance imaging sequence evaluation of an MR Linac system; early clinical experienceen
dc.typeArticleen
dc.contributor.departmentThe Royal Marsden NHS Foundation Trust, London,en
dc.identifier.journalTechnical Innovations and Patient Support in Radiation Oncologyen
dc.description.noteen]
refterms.dateFOA2020-03-31T10:24:24Z


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