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dc.contributor.authorGalvani, Elena
dc.contributor.authorMundra, Piyushkumar A
dc.contributor.authorValpione, Sara
dc.contributor.authorGarcia-Martinez, Pablo
dc.contributor.authorSmith, Matthew
dc.contributor.authorGreenall, Jonathan
dc.contributor.authorThakur, R
dc.contributor.authorHelmink, B
dc.contributor.authorAndrews, MC
dc.contributor.authorBoon, L
dc.contributor.authorChester, Christopher P E
dc.contributor.authorGremel, Gabriela
dc.contributor.authorHogan, Kate
dc.contributor.authorMandal, Amit
dc.contributor.authorZeng, Kang
dc.contributor.authorBanyard, Antonia
dc.contributor.authorAshton, Garry
dc.contributor.authorCook, Martin G
dc.contributor.authorLorigan, Paul C
dc.contributor.authorWargo, JA
dc.contributor.authorDhomen, Nathalie
dc.contributor.authorMarais, Richard
dc.date.accessioned2020-03-27T09:27:58Z
dc.date.available2020-03-27T09:27:58Z
dc.date.issued2020en
dc.identifier.citationGalvani E, Mundra PA, Valpione S, Garcia-Martinez P, Smith M, Greenall J, et al. Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma. Nat Commun. 2020;11:853.en
dc.identifier.pmid32051401en
dc.identifier.doi10.1038/s41467-020-14632-2en
dc.identifier.urihttp://hdl.handle.net/10541/622816
dc.description.abstractAlthough immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by these drugs remain unknown. Here we show the genetic and phenotypic changes induced by treatment with programmed cell death-1 (PD-1) blockade in a genetically engineered mouse model of melanoma driven by oncogenic BRAF. In this controlled system anti-PD-1 treatment yields responses in ~35% of the tumors, and prolongs survival in ~27% of the animals. We identify increased stroma remodeling and reduced expression of proliferation markers as features associated with prolonged response. These traits are corroborated in two independent early on-treatment anti-PD-1 melanoma patient cohorts. These insights into the biological responses of tumors to ICI provide a strategy for identification of durable response early during the course of treatment and could improve patient stratification for checkpoint inhibitory drugs.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-020-14632-2en
dc.titleStroma remodeling and reduced cell division define durable response to PD-1 blockade in melanomaen
dc.typeArticleen
dc.contributor.departmentMolecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Manchester,en
dc.identifier.journalNature Communicationsen
dc.description.noteen]
refterms.dateFOA2020-03-30T13:02:08Z


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