New approaches to small cell lung cancer therapy : from the laboratory to the clinic
Authors
Poirier, JTGeorge, J
Owonikoko, TK
Berns, A
Brambilla, E
Byers, LA
Carbone, D
Chen, HJ
Christensen, CL
Dive, Caroline
Farago, AF
Govindan, R
Hann, C
Hellmann, MD
Horn, L
Johnson, JE
Ju, YS
Kang, S
Krasnow, M
Lee, J
Lee, SH
Lehman, J
Lok, B
Lovly, C
MacPherson, D
McFadden, D
Minna, J
Oser, M
Park, K
Park, KS
Pommier, Y
Quaranta, V
Ready, N
Sage, J
Scagliotti, G
Sos, ML
Sutherland, KD
Travis, WD
Vakoc, CR
Wait, SJ
Wistuba, I
Wong, KK
Zhang, H
Daigneault, J
Wiens, J
Rudin, CM
Oliver, TG
Affiliation
Perlmutter Cancer Center, New York University Langone Health, New York, NY, USAIssue Date
2020
Metadata
Show full item recordAbstract
Small cell lung cancer patient outcomes have not yet been significantly impacted by the revolution in precision oncology, primarily due to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. While these results are encouraging, many patients do not respond to or rapidly recur after current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion is a snapshot of the current biomarker and clinical trial landscapes for small cell lung cancer. Finally, we identify key knowledge gaps that should be addressed in order to advance the field in pursuit of reduced small cell lung cancer mortality. This review largely summarizes work presented at the Third Biennial IASLC Small Cell Lung Cancer Meeting.Citation
Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, et al. New approaches to small cell lung cancer therapy : from the laboratory to the clinic. J Thorac Oncol. 2020.Journal
Journal of Thoracic OncologyDOI
10.1016/j.jtho.2020.01.016PubMed ID
32018053Additional Links
https://dx.doi.org/10.1016/j.jtho.2020.01.016Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.jtho.2020.01.016