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    New approaches to small cell lung cancer therapy : from the laboratory to the clinic

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    Authors
    Poirier, JT
    George, J
    Owonikoko, TK
    Berns, A
    Brambilla, E
    Byers, LA
    Carbone, D
    Chen, HJ
    Christensen, CL
    Dive, Caroline
    Farago, AF
    Govindan, R
    Hann, C
    Hellmann, MD
    Horn, L
    Johnson, JE
    Ju, YS
    Kang, S
    Krasnow, M
    Lee, J
    Lee, SH
    Lehman, J
    Lok, B
    Lovly, C
    MacPherson, D
    McFadden, D
    Minna, J
    Oser, M
    Park, K
    Park, KS
    Pommier, Y
    Quaranta, V
    Ready, N
    Sage, J
    Scagliotti, G
    Sos, ML
    Sutherland, KD
    Travis, WD
    Vakoc, CR
    Wait, SJ
    Wistuba, I
    Wong, KK
    Zhang, H
    Daigneault, J
    Wiens, J
    Rudin, CM
    Oliver, TG
    Show allShow less
    Affiliation
    Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA
    Issue Date
    2020
    
    Metadata
    Show full item record
    Abstract
    Small cell lung cancer patient outcomes have not yet been significantly impacted by the revolution in precision oncology, primarily due to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. While these results are encouraging, many patients do not respond to or rapidly recur after current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion is a snapshot of the current biomarker and clinical trial landscapes for small cell lung cancer. Finally, we identify key knowledge gaps that should be addressed in order to advance the field in pursuit of reduced small cell lung cancer mortality. This review largely summarizes work presented at the Third Biennial IASLC Small Cell Lung Cancer Meeting.
    Citation
    Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, et al. New approaches to small cell lung cancer therapy : from the laboratory to the clinic. J Thorac Oncol. 2020.
    Journal
    Journal of Thoracic Oncology
    URI
    http://hdl.handle.net/10541/622787
    DOI
    10.1016/j.jtho.2020.01.016
    PubMed ID
    32018053
    Additional Links
    https://dx.doi.org/10.1016/j.jtho.2020.01.016
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jtho.2020.01.016
    Scopus Count
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    All Paterson Institute for Cancer Research

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