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dc.contributor.authorLie-A-Ling, Michael
dc.contributor.authorMevel, Renaud
dc.contributor.authorPatel, Rahima
dc.contributor.authorBlyth, K
dc.contributor.authorBaena, Esther
dc.contributor.authorKouskoff, V
dc.contributor.authorLacaud, Georges
dc.date.accessioned2020-02-27T16:55:26Z
dc.date.available2020-02-27T16:55:26Z
dc.date.issued2020en
dc.identifier.citationLie-a-ling M, Mevel R, Patel R, Blyth K, Baena E, Kouskoff V, et al. RUNX1 Dosage in Development and Cancer. Mol Cells. 2020;43(2):126-38.en
dc.identifier.pmid31991535en
dc.identifier.doi10.14348/molcells.2019.0301en
dc.identifier.urihttp://hdl.handle.net/10541/622772
dc.description.abstractThe transcription factor RUNX1 first came to prominence due to its involvement in the t(8;21) translocation in acute myeloid leukemia (AML). Since this discovery, RUNX1 has been shown to play important roles not only in leukemia but also in the ontogeny of the normal hematopoietic system. Although it is currently still challenging to fully assess the different parameters regulating RUNX1 dosage, it has become clear that the dose of RUNX1 can greatly affect both leukemia and normal hematopoietic development. It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RUNX1 dosage in normal development of both hematopoietic and epithelial tissues and their associated cancers.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.14348/molcells.2019.0301en
dc.titleRUNX1 dosage in development and canceren
dc.typeArticleen
dc.contributor.departmentCancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfield, SK10 4TG, UKen
dc.identifier.journalMolecules and Cellsen
dc.description.noteen]
refterms.dateFOA2020-11-27T17:20:06Z


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