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dc.contributor.authorSahai, E
dc.contributor.authorAstsaturov, I
dc.contributor.authorCukierman, E
dc.contributor.authorDeNardo, DG
dc.contributor.authorEgeblad, M
dc.contributor.authorEvans, RM
dc.contributor.authorFearon, D
dc.contributor.authorGreten, FR
dc.contributor.authorHingorani, SR
dc.contributor.authorHunter, T
dc.contributor.authorHynes, RO
dc.contributor.authorJain, RK
dc.contributor.authorJanowitz, T
dc.contributor.authorJorgensen, Claus
dc.contributor.authorKimmelman, AC
dc.contributor.authorKolonin, MG
dc.contributor.authorMaki, RG
dc.contributor.authorPowers, RS
dc.contributor.authorPure, E
dc.contributor.authorRamirez, DC
dc.contributor.authorScherz-Shouval, R
dc.contributor.authorSherman, MH
dc.contributor.authorStewart, S
dc.contributor.authorTlsty, TD
dc.contributor.authorTuveson, DA
dc.contributor.authorWatt, FM
dc.contributor.authorWeaver, V
dc.contributor.authorWeeraratna, AT
dc.contributor.authorWerb, Z
dc.date.accessioned2020-02-27T16:55:25Z
dc.date.available2020-02-27T16:55:25Z
dc.date.issued2020en
dc.identifier.citationSahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020.en
dc.identifier.pmid31980749en
dc.identifier.doi10.1038/s41568-019-0238-1en
dc.identifier.urihttp://hdl.handle.net/10541/622767
dc.description.abstractCancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41568-019-0238-1en
dc.titleA framework for advancing our understanding of cancer-associated fibroblastsen
dc.typeArticleen
dc.contributor.departmentThe Francis Crick Institute, London, UKen
dc.identifier.journalNature Reviews Canceren
dc.description.noteen]
refterms.dateFOA2020-03-04T10:37:47Z


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