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dc.contributor.authorEscala-Garcia, M
dc.contributor.authorAbraham, J
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAshworth, A
dc.contributor.authorAuer, PL
dc.contributor.authorAuvinen, P
dc.contributor.authorBeckmann, MW
dc.contributor.authorBeesley, J
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBlomqvist, C
dc.contributor.authorBlot, W
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorBorresen-Dale, AL
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrucker, SY
dc.contributor.authorBurwinkel, B
dc.contributor.authorCaldas, C
dc.contributor.authorCanzian, F
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChin, SF
dc.contributor.authorClarke, CL
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorDennis, J
dc.contributor.authorDevilee, P
dc.contributor.authorDunn, JA
dc.contributor.authorDunning, AM
dc.contributor.authorDwek, M
dc.contributor.authorEarl, HM
dc.contributor.authorEccles, DM
dc.contributor.authorEliassen, AH
dc.contributor.authorEllberg, C
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFlyger, H
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorGarcia-Saenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGeorge, A
dc.contributor.authorGiles, GG
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzalez-Neira, A
dc.contributor.authorGrip, M
dc.contributor.authorGuenel, P
dc.contributor.authorGuo, Q
dc.contributor.authorHaiman, CA
dc.contributor.authorHakansson, N
dc.contributor.authorHamann, U
dc.contributor.authorHarrington, PA
dc.contributor.authorHiller, L
dc.contributor.authorHooning, MJ
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, Anthony
dc.contributor.authorHuang, CS
dc.contributor.authorHuang, G
dc.contributor.authorHunter, DJ
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorKaaks, R
dc.contributor.authorKapoor, PM
dc.contributor.authorKeeman, R
dc.contributor.authorKitahara, CM
dc.contributor.authorKoppert, LB
dc.contributor.authorKraft, P
dc.contributor.authorKristensen, VN
dc.contributor.authorLambrechts, D
dc.contributor.authorLe Marchand, L
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLindblom, A
dc.contributor.authorLubinski, J
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMaurer, T
dc.contributor.authorMavroudis, D
dc.contributor.authorMeindl, A
dc.contributor.authorMilne, RL
dc.contributor.authorMulligan, AM
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewman, WG
dc.contributor.authorOlshan, AF
dc.contributor.authorOlson, JE
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorPeterlongo, P
dc.contributor.authorPetridis, C
dc.contributor.authorPrentice, RL
dc.contributor.authorPresneau, N
dc.contributor.authorPunie, K
dc.contributor.authorRamachandran, D
dc.contributor.authorRennert, G
dc.contributor.authorRomero, A
dc.contributor.authorSachchithananthan, M
dc.contributor.authorSaloustros, E
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchwentner, L
dc.contributor.authorScott, C
dc.contributor.authorSimard, J
dc.contributor.authorSohn, C
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTamimi, RM
dc.contributor.authorTapper, WJ
dc.contributor.authorTeixeira, MR
dc.contributor.authorTerry, MB
dc.contributor.authorThorne, H
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTomlinson, I
dc.contributor.authorTroester, MA
dc.contributor.authorTruong, T
dc.contributor.authorTurnbull, C
dc.contributor.authorVachon, CM
dc.contributor.authorVan der Kolk, LE
dc.contributor.authorWang, Q
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorYang, XR
dc.contributor.authorZiogas, A
dc.contributor.authorPharoah, PDP
dc.contributor.authorHall, P
dc.contributor.authorWessels, LFA
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorBader, GD
dc.contributor.authorDork, T
dc.contributor.authorEaston, DF
dc.contributor.authorCanisius, S
dc.contributor.authorSchmidt, MK
dc.date.accessioned2020-02-27T16:55:23Z
dc.date.available2020-02-27T16:55:23Z
dc.date.issued2020en
dc.identifier.citationEscala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A, et al. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nat Commun. 2020;11(1):312.en
dc.identifier.pmid31949161en
dc.identifier.doi10.1038/s41467-019-14100-6en
dc.identifier.urihttp://hdl.handle.net/10541/622753
dc.description.abstractIdentifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-019-14100-6en
dc.titleA network analysis to identify mediators of germline-driven differences in breast cancer prognosisen
dc.typeArticleen
dc.contributor.departmentDivision of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlandsen
dc.identifier.journalNature Communicationsen
dc.description.noteen]
refterms.dateFOA2020-03-03T14:03:17Z


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