Show simple item record

dc.contributor.authorAntoniou, N
dc.contributor.authorLagopati, N
dc.contributor.authorBalourdas, DI
dc.contributor.authorNikolaou, M
dc.contributor.authorPapalampros, A
dc.contributor.authorVasileiou, PVS
dc.contributor.authorMyrianthopoulos, V
dc.contributor.authorKotsinas, A
dc.contributor.authorShiloh, Y
dc.contributor.authorLiontos, M
dc.contributor.authorGorgoulis, Vassilis G
dc.date.accessioned2020-01-29T15:18:01Z
dc.date.available2020-01-29T15:18:01Z
dc.date.issued2019en
dc.identifier.citationAntoniou N, Lagopati N, Balourdas DI, Nikolaou M, Papalampros A, Vasileiou PVS, et al. The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies. Cancers (Basel). 2019;12(1).en
dc.identifier.pmid31878315en
dc.identifier.doi10.3390/cancers12010062en
dc.identifier.urihttp://hdl.handle.net/10541/622740
dc.description.abstractThe genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3390/cancers12010062en
dc.titleThe role of E3, E4 ubiquitin ligase (UBE4B) in human pathologiesen
dc.typeArticleen
dc.contributor.departmentMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greeceen
dc.identifier.journalCancersen
dc.description.noteen]
refterms.dateFOA2020-02-04T09:06:09Z


Files in this item

Thumbnail
Name:
31878315.pdf
Size:
3.641Mb
Format:
PDF
Description:
From UNPAYWALL

This item appears in the following Collection(s)

Show simple item record