Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded
Shanks, Jonathan H
AffiliationAquesta Uropathology and University of Queensland, Brisbane, Qld, Australia
MetadataShow full item record
AbstractInfiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.
CitationSamaratunga H, Delahunt B, Egevad L, Srigley JR, Billis A, Bostwick DG, et al. Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology. 2019.
- SOCS3 Immunohistochemical Expression Seems to Support the 2005 and 2014 International Society of Urological Pathology (ISUP) Modified Gleason Grading System.
- Authors: Pierconti F, Martini M, Cenci T, Petrone GL, Ricci R, Sacco E, Bassi PF, Larocca LM
- Issue date: 2017 May
- Intraductal carcinoma of the prostate: a critical re-appraisal.
- Authors: Varma M, Delahunt B, Egevad L, Samaratunga H, Kristiansen G
- Issue date: 2019 May
- Grading of prostate cancer: the impact of including intraductal carcinoma on the overall Grade Group assigned in diagnostic biopsies.
- Authors: Chen-Maxwell D, Prendeville S
- Issue date: 2020 Sep
- Head to head: should the intraductal component of invasive prostate cancer be graded?
- Authors: Varma M, Epstein JI
- Issue date: 2020 Jul 21
- Comparison of prostatic adenocarcinoma Gleason 5 and intraductal carcinoma of the prostate with tumor necrosis. A morphometric study.
- Authors: Acosta AM, Vormittag E, Al Rasheed MRH, Sharif A, Mon KS, Kajdacsy-Balla A, Mohapatra G
- Issue date: 2018 Oct