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    Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded

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    Authors
    Samaratunga, H
    Delahunt, B
    Egevad, L
    Srigley, JR
    Billis, A
    Bostwick, DG
    Camparo, P
    Cheng, L
    Clouston, D
    Denham, J
    Furusato, B
    Hartmann, A
    Jufe, L
    Kench, J
    Kenwright, DN
    Kristiansen, G
    Leite, KRM
    MacLennan, GT
    Merrimen, J
    Moch, H
    Oxley, J
    Pan, CC
    Paner, G
    Ro, J
    Sesterhenn, IAM
    Shanks, Jonathan H
    Thunders, M
    Tsuzuki, T
    Wheeler, T
    Yaxley, JW
    Varma, M
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    Affiliation
    Aquesta Uropathology and University of Queensland, Brisbane, Qld, Australia
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Infiltration of the prostatic ducts by prostatic adenocarcinoma occurs relatively frequently, being most commonly associated with high grade disease. It is now recognised that intraductal carcinoma of the prostate (IDCP) has an associated poor prognosis and this is reflected in its histological, molecular and immunohistochemical features. The current recommendation of the World Health Organization is that IDCP not be taken into consideration when grading prostate adenocarcinoma. It is apparent that Gleason did not differentiate between IDCP and stromal invasive carcinoma when developing and validating his grading system, and recent studies suggest that the incorporation of IDCP grading into the overall grading of the specimen provides additional prognostic information.
    Citation
    Samaratunga H, Delahunt B, Egevad L, Srigley JR, Billis A, Bostwick DG, et al. Intraductal carcinoma of the prostate is an aggressive form of invasive carcinoma and should be graded. Pathology. 2019.
    Journal
    Pathology
    URI
    http://hdl.handle.net/10541/622730
    DOI
    10.1016/j.pathol.2019.11.001
    PubMed ID
    31843189
    Additional Links
    https://dx.doi.org/10.1016/j.pathol.2019.11.001
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pathol.2019.11.001
    Scopus Count
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    All Christie Publications

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