AffiliationDivision of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
MetadataShow full item record
AbstractThe incidence of breast cancer continues to increase worldwide. Population-based screening is available in many countries but may not be the most efficient use of resources, thus interest in risk-based/stratified screening has grown significantly in recent years. An important part of risk-based screening is the incorporation of mammographic density (MD) and single nucleotide polymorphisms (SNPs) into risk prediction models to be combined with classical risk factors. In this article, we discuss different measures of MD and risk prediction models that are available. Risk-stratified screening options including supplemental or alternative screening modalities including digital breast tomosynthesis (DBT), automated ultrasound (ABUS) and magnetic resonance imaging (MRI) are discussed, as well as potential risk-based interventions (diet and lifestyle, chemoprevention and risk-reducing surgery). Furthermore, we look at risk feedback in practice and the cost-effectiveness and acceptability of risk-based screening, highlighting some of the current challenges.
CitationHarkness EF, Astley SM, Evans DG. Risk-based breast cancer screening strategies in women. Best Pract Res Clin Obstet Gynaecol. 2019.
JournalBest Practice and Research Clinical Obstetrics and Gynaecology
- Personalised screening: is this the way forward?
- Authors: Gilbert FJ, Selamoglu A
- Issue date: 2018 Apr
- Double reading of automated breast ultrasound with digital mammography or digital breast tomosynthesis for breast cancer screening.
- Authors: Lee JM, Partridge SC, Liao GJ, Hippe DS, Kim AE, Lee CI, Rahbar H, Scheel JR, Lehman CD
- Issue date: 2019 May - Jun
- Supplemental Screening for Breast Cancer in Women With Dense Breasts: A Systematic Review for the U.S. Preventive Services Task Force.
- Authors: Melnikow J, Fenton JJ, Whitlock EP, Miglioretti DL, Weyrich MS, Thompson JH, Shah K
- Issue date: 2016 Feb 16