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dc.contributor.authorIrwin, GW
dc.contributor.authorBannon, F
dc.contributor.authorColes, CE
dc.contributor.authorCopson, E
dc.contributor.authorCutress, RI
dc.contributor.authorDave, RV
dc.contributor.authorGrayson, M
dc.contributor.authorHolcombe, C
dc.contributor.authorIrshad, S
dc.contributor.authorO'Brien, Ciara S
dc.contributor.authorO'Connell, RL
dc.contributor.authorPalmieri, C
dc.contributor.authorShaaban, AM
dc.contributor.authorSharma, N
dc.contributor.authorSingh, J
dc.contributor.authorWhitehead, I
dc.contributor.authorPotter, S
dc.contributor.authorMcIntosh, SA
dc.date.accessioned2020-01-29T15:17:58Z
dc.date.available2020-01-29T15:17:58Z
dc.date.issued2019en
dc.identifier.citationIrwin GW, Bannon F, Coles CE, Copson E, Cutress RI, Dave RV, et al. The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer. Int J Surg Protoc. 2019;18:5-11.en
dc.identifier.pmid31897446en
dc.identifier.doi10.1016/j.isjp.2019.10.002en
dc.identifier.urihttp://hdl.handle.net/10541/622717
dc.description.abstractINTRODUCTION: Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK. METHODS AND ANALYSIS: Phase 1 - a national practice questionnaire (NPQ) to survey current practice.Phase 2 - a multi-centre prospective cohort study of breast cancer patients, undergoing NST.Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 and May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ~50 centres are anticipated.Trial registration: ISRCTN11160072. ETHICS AND DISSEMINATION: Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.isjp.2019.10.002en
dc.titleThe NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast canceren
dc.typeArticleen
dc.contributor.departmentBelfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, Belfast BT98 7AB, UKen
dc.identifier.journalInternational Journal of Surgery Protocolsen
dc.description.noteen]
refterms.dateFOA2020-02-03T16:03:52Z


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