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    The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer

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    Authors
    Irwin, GW
    Bannon, F
    Coles, CE
    Copson, E
    Cutress, RI
    Dave, RV
    Grayson, M
    Holcombe, C
    Irshad, S
    O'Brien, Ciara S
    O'Connell, RL
    Palmieri, C
    Shaaban, AM
    Sharma, N
    Singh, J
    Whitehead, I
    Potter, S
    McIntosh, SA
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    Affiliation
    Belfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, Belfast BT98 7AB, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    INTRODUCTION: Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK. METHODS AND ANALYSIS: Phase 1 - a national practice questionnaire (NPQ) to survey current practice.Phase 2 - a multi-centre prospective cohort study of breast cancer patients, undergoing NST.Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 and May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ~50 centres are anticipated.Trial registration: ISRCTN11160072. ETHICS AND DISSEMINATION: Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.
    Citation
    Irwin GW, Bannon F, Coles CE, Copson E, Cutress RI, Dave RV, et al. The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer. Int J Surg Protoc. 2019;18:5-11.
    Journal
    International Journal of Surgery Protocols
    URI
    http://hdl.handle.net/10541/622717
    DOI
    10.1016/j.isjp.2019.10.002
    PubMed ID
    31897446
    Additional Links
    https://dx.doi.org/10.1016/j.isjp.2019.10.002
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.isjp.2019.10.002
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