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dc.contributor.authorFachal, L
dc.contributor.authorAschard, H
dc.contributor.authorBeesley, J
dc.contributor.authorBarnes, DR
dc.contributor.authorAllen, J
dc.contributor.authorKar, S
dc.contributor.authorPooley, KA
dc.contributor.authorDennis, J
dc.contributor.authorMichailidou, K
dc.contributor.authorTurman, C
dc.contributor.authorSoucy, P
dc.contributor.authorLemacon, A
dc.contributor.authorLush, M
dc.contributor.authorTyrer, JP
dc.contributor.authorGhoussaini, M
dc.contributor.authorMarjaneh, MM
dc.contributor.authorJiang, X
dc.contributor.authorAgata, S
dc.contributor.authorAittomaki, K
dc.contributor.authorAlonso, MR
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, NN
dc.contributor.authorArason, A
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorArun, BK
dc.contributor.authorAuber, B
dc.contributor.authorAuer, PL
dc.contributor.authorAzzollini, J
dc.contributor.authorBalmana, J
dc.contributor.authorBarkardottir, RB
dc.contributor.authorBarrowdale, D
dc.contributor.authorBeeghly-Fadiel, A
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBialkowska, K
dc.contributor.authorBlanco, AM
dc.contributor.authorBlomqvist, C
dc.contributor.authorBlot, W
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBolla, MK
dc.contributor.authorBonanni, B
dc.contributor.authorBorg, A
dc.contributor.authorBosse, K
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBriceno, I
dc.contributor.authorBrock, IW
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorBruning, T
dc.contributor.authorBurwinkel, B
dc.contributor.authorBuys, SS
dc.contributor.authorCai, Q
dc.contributor.authorCaldes, T
dc.contributor.authorCaligo, MA
dc.contributor.authorCamp, NJ
dc.contributor.authorCampbell, I
dc.contributor.authorCanzian, F
dc.contributor.authorCarroll, JS
dc.contributor.authorCarter, BD
dc.contributor.authorCastelao, JE
dc.contributor.authorChiquette, J
dc.contributor.authorChristiansen, H
dc.contributor.authorChung, WK
dc.contributor.authorClaes, KBM
dc.contributor.authorClarke, CL
dc.contributor.authorCollee, JM
dc.contributor.authorCornelissen, S
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCybulski, C
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorde la Hoya, M
dc.contributor.authorDevilee, P
dc.contributor.authorDiez, O
dc.contributor.authorDing, YC
dc.contributor.authorDite, GS
dc.contributor.authorDomchek, SM
dc.contributor.authorDork, T
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorDroit, A
dc.contributor.authorDubois, S
dc.contributor.authorDumont, M
dc.contributor.authorDuran, M
dc.contributor.authorDurcan, L
dc.contributor.authorDwek, M
dc.contributor.authorEccles, DM
dc.contributor.authorEngel, C
dc.contributor.authorEriksson, M
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFletcher, O
dc.contributor.authorFloris, G
dc.contributor.authorFlyger, H
dc.contributor.authorForetova, L
dc.contributor.authorFoulkes, WD
dc.contributor.authorFriedman, E
dc.contributor.authorFritschi, L
dc.contributor.authorFrost, D
dc.contributor.authorGabrielson, M
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGambino, G
dc.contributor.authorGanz, PA
dc.contributor.authorGapstur, SM
dc.contributor.authorGarber, J
dc.contributor.authorGarcia-Saenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGeorgoulias, V
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGoldberg, MS
dc.contributor.authorGoldgar, DE
dc.contributor.authorGonzalez-Neira, A
dc.contributor.authorTibiletti, MG
dc.contributor.authorGreene, MH
dc.contributor.authorGrip, M
dc.contributor.authorGronwald, J
dc.contributor.authorGrundy, A
dc.contributor.authorGuenel, P
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHakansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHarrington, PA
dc.contributor.authorHartikainen, JM
dc.contributor.authorHartman, M
dc.contributor.authorHe, W
dc.contributor.authorHealey, CS
dc.contributor.authorHeemskerk-Gerritsen, BAM
dc.contributor.authorHeyworth, J
dc.contributor.authorHillemanns, P
dc.contributor.authorHogervorst, FBL
dc.contributor.authorHollestelle, A
dc.contributor.authorHooning, MJ
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, Anthony
dc.contributor.authorHuang, G
dc.contributor.authorHulick, PJ
dc.contributor.authorImyanitov, EN
dc.contributor.authorIsaacs, C
dc.contributor.authorIwasaki, M
dc.contributor.authorJager, A
dc.contributor.authorJakimovska, M
dc.contributor.authorJakubowska, A
dc.contributor.authorJames, PA
dc.contributor.authorJanavicius, R
dc.contributor.authorJankowitz, RC
dc.contributor.authorJohn, EM
dc.contributor.authorJohnson, N
dc.contributor.authorJones, ME
dc.contributor.authorJukkola-Vuorinen, A
dc.contributor.authorJung, A
dc.contributor.authorKaaks, R
dc.contributor.authorKang, D
dc.contributor.authorKapoor, PM
dc.contributor.authorKarlan, BY
dc.contributor.authorKeeman, R
dc.contributor.authorKerin, MJ
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiiski, JI
dc.contributor.authorKirk, J
dc.contributor.authorKitahara, CM
dc.contributor.authorKo, YD
dc.contributor.authorKonstantopoulou, I
dc.contributor.authorKosma, VM
dc.contributor.authorKoutros, S
dc.contributor.authorKubelka-Sabit, K
dc.contributor.authorKwong, A
dc.contributor.authorKyriacou, K
dc.contributor.authorLaitman, Y
dc.contributor.authorLambrechts, D
dc.contributor.authorLee, E
dc.contributor.authorLeslie, G
dc.contributor.authorLester, J
dc.contributor.authorLesueur, F
dc.contributor.authorLindblom, A
dc.contributor.authorLo, WY
dc.contributor.authorLong, J
dc.contributor.authorLophatananon, A
dc.contributor.authorLoud, JT
dc.contributor.authorLubinski, J
dc.contributor.authorMacInnis, RJ
dc.contributor.authorMaishman, T
dc.contributor.authorMakalic, E
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMatsuo, K
dc.contributor.authorMaurer, T
dc.contributor.authorMavroudis, D
dc.contributor.authorMayes, R
dc.contributor.authorMcGuffog, L
dc.contributor.authorMcLean, C
dc.contributor.authorMebirouk, N
dc.contributor.authorMeindl, A
dc.contributor.authorMiller, A
dc.contributor.authorMiller, N
dc.contributor.authorMontagna, M
dc.contributor.authorMoreno, F
dc.contributor.authorMuir, K
dc.contributor.authorMulligan, AM
dc.contributor.authorMunoz-Garzon, VM
dc.contributor.authorMuranen, TA
dc.contributor.authorNarod, SA
dc.contributor.authorNassir, R
dc.contributor.authorNathanson, KL
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNeven, P
dc.contributor.authorNielsen, FC
dc.contributor.authorNikitina-Zake, L
dc.contributor.authorNorman, A
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorOlopade, OI
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorOsorio, A
dc.contributor.authorPankratz, VS
dc.contributor.authorPapp, J
dc.contributor.authorPark, SK
dc.contributor.authorPark-Simon, TW
dc.contributor.authorParsons, MT
dc.contributor.authorPaul, J
dc.contributor.authorPedersen, IS
dc.contributor.authorPeissel, B
dc.contributor.authorPeshkin, B
dc.contributor.authorPeterlongo, P
dc.contributor.authorPeto, J
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPrajzendanc, K
dc.contributor.authorPrentice, R
dc.contributor.authorPresneau, N
dc.contributor.authorProkofyeva, D
dc.contributor.authorPujana, MA
dc.contributor.authorPylkas, K
dc.contributor.authorRadice, P
dc.contributor.authorRamus, SJ
dc.contributor.authorRantala, J
dc.contributor.authorRau-Murthy, R
dc.contributor.authorRennert, G
dc.contributor.authorRisch, HA
dc.contributor.authorRobson, M
dc.contributor.authorRomero, A
dc.contributor.authorRossing, M
dc.contributor.authorSaloustros, E
dc.contributor.authorSanchez-Herrero, E
dc.date.accessioned2020-01-29T15:17:55Z
dc.date.available2020-01-29T15:17:55Z
dc.date.issued2020en
dc.identifier.citationFachal L, Aschard H, Beesley J, Barnes DR, Allen J, Kar S, et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet. 2020;52(1):56-73.en
dc.identifier.pmid31911677en
dc.identifier.doi10.1038/s41588-019-0537-1en
dc.identifier.urihttp://hdl.handle.net/10541/622711
dc.description.abstractGenome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41588-019-0537-1en
dc.titleFine-mapping of 150 breast cancer risk regions identifies 191 likely target genesen
dc.typeArticleen
dc.contributor.departmentCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UKen
dc.identifier.journalNature Geneticsen
dc.description.noteen]
refterms.dateFOA2020-11-27T17:26:11Z


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