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dc.contributor.authorWang, Pengbo
dc.contributor.authorWu, J
dc.contributor.authorWood, A
dc.contributor.authorJones, M
dc.contributor.authorPedley, R
dc.contributor.authorLi, W
dc.contributor.authorRoss, RS
dc.contributor.authorBallestrem, C
dc.contributor.authorGilmore, AP
dc.contributor.authorStreuli, CH
dc.date.accessioned2020-01-29T15:17:49Z
dc.date.available2020-01-29T15:17:49Z
dc.date.issued2019en
dc.identifier.citationWang P, Wu J, Wood A, Jones M, Pedley R, Li W, et al. Vinculins interaction with talin is essential for mammary epithelial differentiation. Sci Rep. 2019;9(1):18400.en
dc.identifier.pmid31804547en
dc.identifier.doi10.1038/s41598-019-54784-wen
dc.identifier.urihttp://hdl.handle.net/10541/622675
dc.description.abstractVinculin is an essential component of cell adhesion complexes, where it regulates the strength and stability of adhesions. Whilst the role of vinculin in cell motility is well established, it remains unclear how vinculin contributes to other aspects of tissue function. Here we examine the role of vinculin in mammary epithelial cell phenotype. In these cells, correct adhesion to the extracellular matrix is essential for both the formation of polarised secretory acini and for the transcription of tissue-specific milk protein genes. We show that vinculin, through its interaction with talin, controls milk protein gene expression. However, vinculin is not required for the formation of polarised acini. This work reveals new roles for vinculin that are central to cellular differentiation, and for the ability of cells to interpret their extracellular microenvironment.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41598-019-54784-wen
dc.titleVinculins interaction with talin is essential for mammary epithelial differentiationen
dc.typeArticleen
dc.contributor.departmentWellcome Centre for Cell-Matrix Research, FBMH, University of Manchester, Manchesteren
dc.identifier.journalScientific reportsen
dc.description.noteen]
refterms.dateFOA2020-02-03T15:30:15Z


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