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    Vinculins interaction with talin is essential for mammary epithelial differentiation

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    Authors
    Wang, Pengbo
    Wu, J
    Wood, A
    Jones, M
    Pedley, R
    Li, W
    Ross, RS
    Ballestrem, C
    Gilmore, AP
    Streuli, CH
    Affiliation
    Wellcome Centre for Cell-Matrix Research, FBMH, University of Manchester, Manchester
    Issue Date
    2019
    
    Metadata
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    Abstract
    Vinculin is an essential component of cell adhesion complexes, where it regulates the strength and stability of adhesions. Whilst the role of vinculin in cell motility is well established, it remains unclear how vinculin contributes to other aspects of tissue function. Here we examine the role of vinculin in mammary epithelial cell phenotype. In these cells, correct adhesion to the extracellular matrix is essential for both the formation of polarised secretory acini and for the transcription of tissue-specific milk protein genes. We show that vinculin, through its interaction with talin, controls milk protein gene expression. However, vinculin is not required for the formation of polarised acini. This work reveals new roles for vinculin that are central to cellular differentiation, and for the ability of cells to interpret their extracellular microenvironment.
    Citation
    Wang P, Wu J, Wood A, Jones M, Pedley R, Li W, et al. Vinculins interaction with talin is essential for mammary epithelial differentiation. Sci Rep. 2019;9(1):18400.
    Journal
    Scientific reports
    URI
    http://hdl.handle.net/10541/622675
    DOI
    10.1038/s41598-019-54784-w
    PubMed ID
    31804547
    Additional Links
    https://dx.doi.org/10.1038/s41598-019-54784-w
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-54784-w
    Scopus Count
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    All Paterson Institute for Cancer Research

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