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dc.contributor.authorPanaino, Costanza MV
dc.contributor.authorMackay, Ranald I
dc.contributor.authorKirkby, Karen J
dc.contributor.authorTaylor, Michael J
dc.date.accessioned2020-01-29T15:17:48Z
dc.date.available2020-01-29T15:17:48Z
dc.date.issued2019en
dc.identifier.citationPanaino CMV, Mackay RI, Kirkby KJ, Taylor MJ. A New Method to Reconstruct in 3D the Emission Position of the Prompt Gamma Rays following Proton Beam Irradiation. Sci Rep. 2019;9(1):18820.en
dc.identifier.pmid31827167en
dc.identifier.doi10.1038/s41598-019-55349-7en
dc.identifier.urihttp://hdl.handle.net/10541/622665
dc.description.abstractA new technique for range verification in proton beam therapy has been developed. It is based on the detection of the prompt ? rays that are emitted naturally during the delivery of the treatment. A spectrometer comprising 16 LaBr3(Ce) detectors in a symmetrical configuration is employed to record the prompt ? rays emitted along the proton path. An algorithm has been developed that takes as inputs the LaBr3(Ce) detector signals and reconstructs the maximum ?-ray intensity peak position, in full 3 dimensions. For a spectrometer radius of 8?cm, which could accommodate a paediatric head and neck case, the prompt ?-ray origin can be determined from the width of the detected peak with a ? of 4.17?mm for a 180?MeV proton beam impinging a water phantom. For spectrometer radii of 15 and 25?cm to accommodate larger volumes this value increases to 5.65 and 6.36?mm. For a 8?cm radius, with a 5 and 10?mm undershoot, the ? is 4.31 and 5.47?mm. These uncertainties are comparable to the range uncertainties incorporated in treatment planning. This work represents the first step towards a new accurate, real-time, 3D range verification device for spot-scanning proton beam therapy.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41598-019-55349-7en
dc.titleA new method to reconstruct in 3D the emission position of the prompt gamma rays following proton beam irradiationen
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences, University of Manchester, M13 9PLen
dc.identifier.journalScientific reportsen
dc.description.noteen]
refterms.dateFOA2020-02-03T15:08:20Z


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