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    A new method to reconstruct in 3D the emission position of the prompt gamma rays following proton beam irradiation

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    Authors
    Panaino, Costanza MV
    Mackay, Ranald I
    Kirkby, Karen J
    Taylor, Michael J
    Affiliation
    Division of Cancer Sciences, University of Manchester, M13 9PL
    Issue Date
    2019
    
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    Abstract
    A new technique for range verification in proton beam therapy has been developed. It is based on the detection of the prompt ? rays that are emitted naturally during the delivery of the treatment. A spectrometer comprising 16 LaBr3(Ce) detectors in a symmetrical configuration is employed to record the prompt ? rays emitted along the proton path. An algorithm has been developed that takes as inputs the LaBr3(Ce) detector signals and reconstructs the maximum ?-ray intensity peak position, in full 3 dimensions. For a spectrometer radius of 8?cm, which could accommodate a paediatric head and neck case, the prompt ?-ray origin can be determined from the width of the detected peak with a ? of 4.17?mm for a 180?MeV proton beam impinging a water phantom. For spectrometer radii of 15 and 25?cm to accommodate larger volumes this value increases to 5.65 and 6.36?mm. For a 8?cm radius, with a 5 and 10?mm undershoot, the ? is 4.31 and 5.47?mm. These uncertainties are comparable to the range uncertainties incorporated in treatment planning. This work represents the first step towards a new accurate, real-time, 3D range verification device for spot-scanning proton beam therapy.
    Citation
    Panaino CMV, Mackay RI, Kirkby KJ, Taylor MJ. A New Method to Reconstruct in 3D the Emission Position of the Prompt Gamma Rays following Proton Beam Irradiation. Sci Rep. 2019;9(1):18820.
    Journal
    Scientific reports
    URI
    http://hdl.handle.net/10541/622665
    DOI
    10.1038/s41598-019-55349-7
    PubMed ID
    31827167
    Additional Links
    https://dx.doi.org/10.1038/s41598-019-55349-7
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-55349-7
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