• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Standardised quantitative radioiodine SPECT/CT imaging for multicentre dosimetry trials in molecular radiotherapy

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    31766032.pdf
    Size:
    1.209Mb
    Format:
    PDF
    Description:
    From UNPAYWALL
    Download
    Authors
    Gregory, RA
    Murray, I
    Gear, J
    Leek, F
    Chittenden, SJ
    Fenwick, A
    Wevrett, J
    Scuffham, J
    Tipping, Jill
    Murby, Brian
    Jeans, Steve
    Stuffins, M
    Michopoulou, S
    Guy, M
    Morgan, D
    Hallam, A
    Hall, D
    Polydor, H
    Brown, C
    Gillen, G
    Dickinson, N
    Brown, S
    Wadsley, J
    Flux, G
    Show allShow less
    Affiliation
    Barts Health NHS Trust, London, United Kingdom
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    The SEL-I-METRY trial (EudraCT No 2015-002269-47) is the first multicentre trial to investigate the role of 123I and 131I SPECT/CT-based tumour dosimetry to predict response to radioiodine therapy. Standardised dosimetry methodology is essential to provide a robust evidence-base for absorbed dose-response thresholds for molecular radiotherapy (MRT). In this paper a practical standardised protocol is used to establish the first network of centres with consistent methods of radioiodine activity quantification. Nine SPECT/CT systems at eight centres were set-up for quantitative radioiodine imaging. The dead-time of the systems was characterised for up to 2.8 GBq 131I. Volume dependent calibration factors were measured on centrally reconstructed images of 123I and 131I in six (0.8-196?ml) cylinders. Validation of image quantification using these calibration factors was performed on three systems, by imaging a 3D-printed phantom mimicking a patient's activity distribution. The percentage differences between the activities measured in the SPECT/CT image and those measured by the radionuclide calibrator were calculated. Additionally uncertainties on the SPECT/CT-based activities were calculated to indicate the limit on the quantitative accuracy of this method. For systems set-up to image high 131I count rates, the count rate versus activity did not peak below 2.8 GBq and fit a non-paralysable model. The dead-times and volume-dependent calibration factors were comparable between systems of the same model and crystal thickness. Therefore a global calibration curve could be fitted to each. The errors on the validation phantom activities' were comparable to the measurement uncertainties derived from uncertainty analysis, at 10% and 16% on average for 123I and 131I respectively in a 5?cm sphere. In conclusion, the dead-time and calibration factors varied between centres, with different models of system. However, global calibration factors may be applied to the same system model with the same crystal thickness, to simplify set-up of future multi-centre MRT studies.
    Citation
    Gregory RA, Murray I, Gear J, Leek F, Chittenden S, Fenwick A, et al. Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy. Phys Med Biol. 2019;64(24):245013.
    Journal
    Physics in medicine and biology
    URI
    http://hdl.handle.net/10541/622662
    DOI
    10.1088/1361-6560/ab5b6c
    PubMed ID
    31766032
    Additional Links
    https://dx.doi.org/10.1088/1361-6560/ab5b6c
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1088/1361-6560/ab5b6c
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology.
    • Authors: Tran-Gia J, Schlögl S, Lassmann M
    • Issue date: 2016 Dec
    • Whole-remnant and maximum-voxel SPECT/CT dosimetry in (131) I-NaI treatments of differentiated thyroid cancer.
    • Authors: Mínguez P, Flux G, Genollá J, Delgado A, Rodeño E, Sjögreen Gleisner K
    • Issue date: 2016 Oct
    • Impact of missing attenuation and scatter corrections on (99m) Tc-MAA SPECT 3D dosimetry for liver radioembolization using the patient relative calibration methodology: A retrospective investigation on clinical images.
    • Authors: Botta F, Ferrari M, Chiesa C, Vitali S, Guerriero F, Nile MC, Mira M, Lorenzon L, Pacilio M, Cremonesi M
    • Issue date: 2018 Apr
    • A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project.
    • Authors: Tran-Gia J, Denis-Bacelar AM, Ferreira KM, Robinson AP, Calvert N, Fenwick AJ, Finocchiaro D, Fioroni F, Grassi E, Heetun W, Jewitt SJ, Kotzassarlidou M, Ljungberg M, McGowan DR, Scott N, Scuffham J, Gleisner KS, Tipping J, Wevrett J, MRTDosimetry Collaboration, Lassmann M
    • Issue date: 2021 Jul 23
    • Accurate dosimetry in 131I radionuclide therapy using patient-specific, 3-dimensional methods for SPECT reconstruction and absorbed dose calculation.
    • Authors: Dewaraja YK, Wilderman SJ, Ljungberg M, Koral KF, Zasadny K, Kaminiski MS
    • Issue date: 2005 May
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.